Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 431-440 of 452 results
Scientific Reports, 2017 • March 8, 2017
This study aimed to determine the effect of a high-glucose diet on Achilles tendon healing in a rat model. The results indicated that a high-glucose diet significantly affects tendon healing after inj...
KEY FINDING: A high-glucose diet increased tendon repair tissue thickness and stiffness after 2 weeks in rats.
Acta Orthopaedica et Traumatologica Turcica, 2017 • April 25, 2017
This study aimed to evaluate the effect of PRP on spinal cord injury repair in a rat model. The results showed that motor recovery was significantly better in rats treated with PRP 24 hours after inju...
KEY FINDING: Motor recovery was significantly better in rats treated with PRP 24 hours after injury compared to the control group.
International Journal of Molecular Sciences, 2018 • January 9, 2018
This study investigated the effects of intraarticular administration of MSCs in a rat model of shoulder arthritis induced by MIA. The findings indicate that MSCs can inhibit central sensitization of p...
KEY FINDING: Intraarticular injection of MSCs decreased the expression of CGRP in the spinal dorsal horn, indicating a suppression of central sensitization of pain.
Therapeutics and Clinical Risk Management, 2018 • January 1, 2018
This prospective safety study evaluated the impact of BMP-7 on cytokine expression in non-union therapy by comparing IGF-1, PDGF-AB, and TGF-β levels in patients treated with ABG alone versus ABG with...
KEY FINDING: IGF-1 levels were generally higher in the ABG-only group (G2) compared to the BMP-7 group (G1), but the overall course of expression was similar.
Trials, 2018 • May 10, 2018
This study is a randomized controlled trial designed to evaluate the non-inferiority of bioactive glass (BaG) compared to autologous bone graft (ABG) in treating tibial and femoral non-unions using th...
KEY FINDING: The primary endpoint of the study is union achieved 1 year after surgery.
International Journal of Molecular Sciences, 2018 • June 5, 2018
This study compares the effects of IGF-1 and BMP-7 on osteogenic differentiation of human mesenchymal stem cells (MSCs) from reaming debris (RMSC) and iliac crest bone marrow (BMSC) in vitro. The resu...
KEY FINDING: BMSC showed a more sensitive reaction towards stimulation with IGF-1, leading to a significantly higher degree of osteogenic differentiation compared to stimulation with BMP-7.
Medical Devices: Evidence and Research, 2018 • January 1, 2018
The study introduces a novel electroceutical device that delivers percutaneous direct current (DC) stimulation to treat severe neurological pain and soft tissue injuries. The device mimics and modulat...
KEY FINDING: Percutaneous DC stimulation significantly reduced pain and attack frequency in a patient with chronic cluster headaches, leading to complete remission for over 3 years.
Diagnostics, 2018 • August 24, 2018
This study investigates the potential of contrast-enhanced ultrasound (CEUS) and cytokine expression analysis (CEA) to predict the outcome of non-union therapy in tibial non-unions. The results sugges...
KEY FINDING: Lower TNF-α expression before surgery was associated with a positive response to non-union therapy.
Journal of Orthopaedic Surgery and Research, 2018 • September 28, 2018
This study explored the use of serum chemokine analysis to predict outcomes in non-union patients undergoing Masquelet therapy. The research identified CCL-3 and IFN-γ as potential biomarkers that, wh...
KEY FINDING: CCL-3 expression was significantly higher in non-responders (NR) compared to responders (R) during the study course (p = 0.002).
Regen. Med., 2018 • October 22, 2018
The study aimed to determine the bone regenerative potential of a cellular allograft uniquely processed from UCB to optimize high MNC count and to enrich cytokine content. The UCBp-CM elevated prolife...
KEY FINDING: UCBp-CM elevated proliferation and migration rates of mesenchymal stem cells (MSCs) and bone marrow stromal cells.