Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 421-430 of 452 results
Journal of Orthopaedic Translation, 2024 • August 22, 2024
This review comprehensively examines the complex relationship between oxidative stress, mitochondrial dysfunction, and IVDD, highlighting potential therapeutic targets and concepts for future research...
KEY FINDING: Excessive ROS causes oxidative damage to DNA, proteins, and lipids within IVD cells, disrupting normal cell signaling and regulation pathways.
European Journal of Trauma and Emergency Surgery, 2025 • January 11, 2025
This study investigates the use of periosteal flaps (PF) to enhance bone healing in non-unions, comparing a vascularized (pedicled) PF to a ligated PF and a control group in a rat femur model. The res...
KEY FINDING: The pedicled periosteal flap (PF) group showed a significantly higher bone volume compared to the other groups after 10 weeks.
Cureus, 2025 • February 20, 2025
The microglial response to SCI is dynamic and multifaceted, involving a complex interplay of pro-inflammatory and anti-inflammatory processes that influence the outcome of the injury. The role of NF-k...
KEY FINDING: NF-kB signaling greatly influences how microglia respond to SCI, impacting inflammation, tissue damage, and the potential for healing.
Frontiers in Physiology, 2025 • March 19, 2025
This study investigates the impact of spinal hypermobility on the development of ossification of the posterior longitudinal ligaments (OPLL) using an in vivo mouse model. The researchers induced hyper...
KEY FINDING: Spinal hypermobility accelerates the progression of ossification in mice with heterotopic ossification of spinal ligaments.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
The study aimed to assess the differences in functional activity, perceived health, and depressive symptoms between individuals with traumatic paraplegia with and without shoulder pain. The results in...
KEY FINDING: Shoulder pain was prevalent in 30% of patients with traumatic paraplegia.
Orthopedic Reviews, 2016 • January 1, 2016
This study evaluated the use of bone marrow aspirate concentrate (BMAC) in conjunction with core decompression for the treatment of femoral head osteonecrosis (FHN). The trial found that while core de...
KEY FINDING: Significant pain reduction and functional improvement were observed postoperatively in both groups.
Acta Orthopaedica, 2016 • July 1, 2016
This study evaluated the effect of a single dose of erythropoietin (EPO) on bone healing in a rabbit long-bone defect model. EPO was administered either locally to the defect or systemically during su...
KEY FINDING: Both local and systemic EPO treatment significantly increased bone formation compared to the control group. Specifically, bone formation was 2.3 to 2.5 times greater in the treatment groups after 12 weeks.
Scientific Reports, 2016 • September 2, 2016
This study investigates the age-related changes in healthy mouse Achilles tendon tissue and identifies a previously unknown role of Sparc in tendons. The findings demonstrate that Sparc expression dec...
KEY FINDING: Sparc expression significantly decreases in healthy-aged mouse Achilles tendons.
Journal of Inflammation Research, 2016 • September 22, 2016
This study aimed to determine if BMP-7 contributes to improved bone regeneration in nonunion therapy by modulation of angiogenic and inflammatory cytokine expression patterns. The study found that BMP...
KEY FINDING: BMP-7 increases VEGF levels, which promote angiogenesis, essential for bone healing.
BioMed Research International, 2016 • October 17, 2016
This study investigated the spatiotemporal changes of CGRP during spinal fusion to explore its role in bone regeneration. The results demonstrated that the early stage of normal spinal fusion is accom...
KEY FINDING: The density of CGRP reached its peak on the 21st day after the spinal fusion surgery in rats.