Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 411-420 of 452 results
Journal of Orthopaedic Surgery and Research, 2024 • January 5, 2024
The study introduces a combined anterior transcorporeal and posterior translaminar approach for full endoscopic treatment of mixed-type two-segment cervical disc herniation (MTCDH). The technique aims...
KEY FINDING: Patients experienced significant symptom and pain reduction post-operatively, as indicated by clinical assessment scales.
Neurospine, 2023 • December 1, 2023
The study aimed to determine which indicator—lumbar vertebral Hounsfield units (HU), vertebral bone quality (VBQ), or bone mineral density (BMD)—is most effective in predicting thoracolumbar fragility...
KEY FINDING: Lumbar vertebral HU exhibited a positive correlation with BMD (p < 0.01).
Cells, 2024 • January 15, 2024
This editorial summarizes a special issue focused on the molecular mechanisms of intervertebral disc (IVD) degeneration and regeneration, highlighting new treatment strategies. The issue includes six ...
KEY FINDING: Hyperbaric oxygen (HBO) intervention may protect against IVD degeneration via mir-107/Wnt3a-β-catenin signaling.
Materials Today Bio, 2024 • February 22, 2024
This study introduces an injectable nanocomposite hydrogel (OGPGM) composed of PGA-Mn nanoparticles, oxidized sodium alginate, and gelatin for treating osteoarthritis (OA). OGPGM exhibits excellent bi...
KEY FINDING: The nanocomposite hydrogel (OGPGM) exhibits excellent biocompatibility, effectively removes ROS from chondrocytes, and reduces inflammatory factors within the joint.
Journal of Orthopaedic Surgery and Research, 2024 • January 1, 2024
This study investigates the therapeutic potential of exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) in treating spinal cord injury (SCI). The findings suggest that UC-MSC-derive...
KEY FINDING: UC-MSC-derived exosomes improved motor ability in SCI rats compared to those without exosome treatment.
European Journal of Medical Research, 2024 • March 11, 2024
The study investigated COMP and ADAMTS7 as potential biomarkers for IVDD. Both animal and human studies showed that COMP and ADAMTS7 expression increased in tissues and serum during IVDD progression....
KEY FINDING: Serum COMP (sCOMP) and serum ADAMTS7 (sADAMTS7) levels increased in a time-dependent manner following IVD damage in the rabbit model.
Stem Cell Research & Therapy, 2024 • May 7, 2024
This study aimed to evaluate potential synergistic effects of hUC-MSC-sEVs with rhBMP-2 in promoting regeneration of a metaphyseal femoral defect in an osteoporotic rat model. The results demonstrated...
KEY FINDING: The co-application of hUC-MSC-sEVs can improve the efficacy of rhBMP-2 to promote the regeneration of osteoporotic bone defects.
Frontiers in Endocrinology, 2024 • May 10, 2024
This study uses Mendelian randomization (MR) to explore the causal relationships between hormonal and reproductive factors (ANM, AAM, LMC, AFB, AFS, ALB) and the prevalence of low back pain (LBP). The...
KEY FINDING: AAM (OR=0.784, 95% CI: 0.689-0.891; p=3.53E-04), AFB (OR=0.558, 95% CI: 0.436-0.715; p=8.97E-06), ALB (OR=0.396, 95% CI: 0.226-0.692; p=0.002), and AFS (OR=0.602, 95% CI: 0.518-0.700; p=3.47E-10) were associated with a decreased risk of LBP.
Journal of Bone and Mineral Metabolism, 2024 • August 30, 2024
The study constructs Enpp1flox/flox/EIIa-Cre mice to model spinal ectopic ossification, providing a basis for future studies on HOTL. These mice exhibit ossified spines and Achilles tendon abnormaliti...
KEY FINDING: Enpp1 deficiency leads to progressive heterotopic ossification (HO), especially in the spine and Achilles tendons, and is associated with progressive degeneration of the knees.
Quant Imaging Med Surg, 2024 • April 10, 2024
The study validated an AI-based MAC algorithm for improving image quality in low-dose CT scans following percutaneous vertebroplasty (PVP). The AI-MAC algorithm demonstrated superior performance compa...
KEY FINDING: AI-MAC demonstrated no significant difference compared to reference images in CT attenuation, image noise, signal-to-noise ratios (SNRs), and contrast-to-noise ratio (CNR).