Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,211-5,220 of 5,401 results
Exp Neurol, 2008 • February 1, 2008
This study was a replication of a previous study to determine if treatment with NEP1-40 enhances growth of corticospinal and serotonergic axons and enhances locomotor recovery after thoracic spinal co...
KEY FINDING: Treatment with NEP1-40 did not robustly enhance regenerative growth of CST axons or 5HT axons.
The Journal of Neuroscience, 2008 • January 30, 2008
This study identifies netrin-1 as a novel oligodendrocyte-associated inhibitor of axonal growth in the adult spinal cord. Netrin-1 and its receptors are expressed in the intact and lesioned adult CNS....
KEY FINDING: Netrin-1 is expressed by mature oligodendrocytes in the adult spinal cord and is enriched near paranodal loops in nodes of Ranvier.
J Physiol, 2008 • January 31, 2008
The study investigated the capacity of propriospinal neurons to mediate descending locomotor commands in the absence of direct bulbospinal pathways in neonatal rats. Staggered spinal cord hemisections...
KEY FINDING: Locomotor-like activity could be evoked by brainstem stimulation even with staggered spinal cord hemisections that disrupted long direct pathways.
Neuroscience, 2008 • March 18, 2008
This study investigated the fate of intramedullary primary sensory projections following a motor efferent lesion in rats. The results showed that unilateral avulsion of lumbosacral ventral roots leads...
KEY FINDING: Ventral root avulsion (VRA) induces degeneration of primary afferent collaterals in the dorsal funiculus in the absence of a direct injury to sensory axons.
BMC Neuroscience, 2008 • February 24, 2008
This study investigated the expression and function of peripherin in the tuberomammillary (TM) neurons of the mouse hypothalamus, revealing that peripherin is produced by histaminergic neurons in this...
KEY FINDING: Peripherin is expressed in the tuberomammillary neurons of the mouse hypothalamus, specifically within histaminergic neurons.
PLoS ONE, 2008 • March 5, 2008
This study explores the therapeutic potential of peripherally-derived BDNF in promoting the regeneration of ascending sensory neurons following spinal cord injury. The research demonstrates that incre...
KEY FINDING: Conditioning lesion of the sciatic nerve induces regeneration of ascending sensory neurons, and this is blocked by injecting BDNF antiserum in the periphery.
Nat Neurosci, 2008 • April 1, 2008
Systemic artemin treatment caused the regeneration of damaged axons, resulting in virtually complete and long-lasting restoration of nociceptive and sensorimotor functions. Artemin, given in six syste...
KEY FINDING: Systemic artemin administration promotes the regrowth of both myelinated and unmyelinated axons through the dorsal root entry zone (DREZ).
Exp Neurol, 2008 • May 1, 2008
This study investigated the efficacy of microinjecting ChABC directly into the injury site in a rat model of spinal cord injury, using a peripheral nerve graft (PNG) to bridge the injury. The results ...
KEY FINDING: Microinjection of ChABC resulted in extensive CSPG digestion around the injury site.
Neurosci Bull, 2008 • April 1, 2008
This study combined olfactory ensheathing glia (OEG) implantation with ex vivo non-viral vector-based neurotrophin-3 (NT-3) gene therapy to enhance regeneration after thoracic spinal cord injury (SCI)...
KEY FINDING: NT-3 production was seen increased both ex vivo and in vivo in pcDNA3.1(+)-NT3 transfected OEGs.
Purinergic Signalling, 2007 • September 25, 2007
This study investigates the potential neuroprotective effects of guanosine in rats with acute spinal cord injury. The researchers hypothesized that guanosine could mitigate secondary injury mechanisms...
KEY FINDING: Guanosine treatment significantly improved motor and sensory functions in rats with spinal cord injury, as measured by open field walking, hind limb placing, foot orienting, inclined plane, and hot plate tests.