Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,221-5,230 of 5,401 results
Exp Neurol, 2008 • June 1, 2008
This study demonstrates that treadmill exercise, even in small amounts, enhances axon regeneration in the peripheral nervous system after injury. Both continuous, low-intensity training (CT) and high-...
KEY FINDING: Treadmill exercise, even in small doses, enhances axon regeneration in the peripheral nervous system.
J Physiol, 2008 • March 27, 2008
The study investigates the impact of olfactory ensheathing glia (OEG) transplantation on the phenotypic characteristics of fast- and slow-twitch hind limb skeletal muscle in rats with completely trans...
KEY FINDING: OEG transplantation results in hind limb skeletal muscle phenotypes that are generally intermediate between paralyzed and control and different from both.
The Journal of Neuroscience, 2008 • April 2, 2008
This study demonstrates that it is possible to inhibit glial scar formation and to facilitate regeneration after SCI using bioactive three-dimensional nanostructures displaying high densities of neuro...
KEY FINDING: Treatment with IKVAV PA after SCI reduced astrogliosis.
The Journal of Neuroscience, 2008 • April 9, 2008
The study examined myelin status in spared axons after spinal cord injury in mice, finding that these axons are largely remyelinated by 12 weeks post-injury. This indicates a positive correlation betw...
KEY FINDING: Spared rubrospinal tract (RST) axons of passage were fully remyelinated 12 weeks after mouse spinal cord contusion injury.
Neurosci Lett., 2008 • June 20, 2008
The study investigates the neuroprotective effects of rolipram, a PDE4 inhibitor, on oligodendrocytes following contusive cervical spinal cord injury (SCI) in rats. Results demonstrate that oligodendr...
KEY FINDING: Spinal cord oligodendrocytes express three PDE4 subtypes (PDE4A, B, D), while microglia express only PDE4B.
Neuron Glia Biol., 2007 • May 1, 2007
The study investigates the use of electrospun polydioxanone (PDS) matrices with aligned or random fibers to guide axonal regeneration after spinal cord injury. The directionality and growth dynamics o...
KEY FINDING: Electrospinning can produce matrices with aligned or randomly oriented fibers, confirmed by 2-D FFT analysis.
Molecular & Cellular Proteomics, 2008 • May 14, 2008
This study demonstrates that aFGF is able to induce effective functional recovery after contusive spinal cord injury in rats. This was achieved through a single injection of aFGF. Proteomics analysis ...
KEY FINDING: aFGF treatment induces functional recovery of locomotion in contusive SCI rats, as demonstrated by improved BBB scores and CBS analysis.
Cell Proliferation, 2008 • January 1, 2008
The study demonstrates that IL-6 and EGF stimulate proliferation of spinal cord-derived NPCs through distinct signalling pathways, JAK2/STAT3 and MAPK, respectively. Inhibition of JAK2 or EGFR prevent...
KEY FINDING: IL-6 and EGF independently stimulate the proliferation of spinal cord-derived NPCs via the JAK2/STAT3 and MAPK pathways, respectively.
Exp Neurol, 2008 • August 1, 2008
This study investigates the urodynamic mechanisms underlying the incomplete recovery of voiding efficiency (VE) following implantation of avulsed lumbosacral ventral roots into the rat conus medullari...
KEY FINDING: The implanted series showed reflex bladder contractions with a significantly shortened urine expulsion phase compared to sham-operated controls.
The Journal of Clinical Investigation, 2008 • July 1, 2008
This study demonstrates that human olfactory ensheathing cells/olfactory nerve fibroblasts (hOECs/ONFs) promote neuroplasticity in murine models of stroke by secreting trophic factors and upregulating...
KEY FINDING: hOECs/ONFs secrete trophic factors, including SDF-1α, and upregulate CXCR4 under oxygen glucose deprivation (OGD) conditions, promoting neurite outgrowth of primary cortical neurons.