Peripherally-Derived BDNF Promotes Regeneration of Ascending Sensory Neurons after Spinal Cord Injury

PLoS ONE, 2008 · DOI: 10.1371/journal.pone.0001707 · Published: March 5, 2008

Simple Explanation

This study investigates whether brain-derived neurotrophic factor (BDNF) from the peripheral nervous system can help regenerate damaged sensory neurons after spinal cord injury. The blood-brain barrier normally restricts BDNF's access to the central nervous system. The researchers used a conditioning lesion of the sciatic nerve to boost BDNF production in sensory neurons. They also injected BDNF into peripheral nerves and tissues to see if it could promote regeneration of ascending sensory neurons. The results showed that increasing BDNF levels in the periphery can indeed promote the regeneration of these sensory neurons and improve motor function after spinal cord injury, suggesting a potential therapeutic approach.

Study Duration

Not specified

Participants

Adult male Sprague-Dawley rats

Evidence Level

Not specified

Key Findings

1
Conditioning lesion of the sciatic nerve induces regeneration of ascending sensory neurons, and this is blocked by injecting BDNF antiserum in the periphery.
2
Delivery of exogenous BDNF into the sciatic nerve or footpad significantly increased regenerating DRG neurons and sensory axons in the injured spinal cord.
3
Injection of BDNF into the footpad in a contusion injury model promoted recovery of motor functions.

Research Summary

This study explores the therapeutic potential of peripherally-derived BDNF in promoting the regeneration of ascending sensory neurons following spinal cord injury. The research demonstrates that increasing endogenous BDNF through conditioning lesions or administering exogenous BDNF in the periphery enhances sensory neuron regeneration and improves motor function recovery. The findings suggest that peripherally-derived BDNF represents a promising therapeutic strategy for spinal cord injuries, bypassing limitations associated with direct CNS administration.

Practical Implications

Therapeutic Potential

Peripherally delivered BDNF could be a therapeutic target for spinal cord injuries.

Drug Delivery

BDNF can be administered via the footpad.

Regeneration Mechanisms

BDNF is key for nerve regeneration after injury.

Study Limitations

1
The precise mechanisms of how peripherally delivered BDNF affects descending neurons remains unclear.
2
The study primarily focused on sensory neurons; the impact on other neuronal populations needs further investigation.
3
Further research is required to optimize the dosage and timing of peripheral BDNF administration for maximal therapeutic efficacy.

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