Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,201-5,210 of 5,401 results
Neurorehabil Neural Repair, 2008 • March 1, 2008
This study investigates the effect of Nogo-66 receptor antagonist peptide (NEP1-40) on functional recovery and axonal growth after lateral funiculus injury in adult rats. The results showed that NEP1-...
KEY FINDING: NEP1-40 treatment led to recovery in gait compared to controls.
Cell Mol Neurobiol, 2008 • December 6, 2007
The study aimed to observe the effect of ultrashortwave (USW) therapy on nerve regeneration after acellular nerve allografts (ANA) repairing the sciatic nerve gap of rats. USW therapy can promote nerv...
KEY FINDING: USW therapy can increase nerve conductive velocity compared to acellular nerve allografts alone.
PPAR Research, 2007 • February 28, 2007
This review discusses the roles of RAR/RXR and PPAR/RXR signaling pathways in physiological reactions after spinal cord injury, highlighting their potential as therapeutic targets. RAR signaling may i...
KEY FINDING: RAR signaling may improve axonal regeneration, influence glial differentiation, and modulate inflammatory reactions after spinal cord injury.
The Journal of Neuroscience, 2007 • December 19, 2007
This study investigates the mechanisms underlying neuromuscular maps by studying the preferential outgrowth of embryonic spinal cord neurites on muscle membranes from different axial positions and exp...
KEY FINDING: Rostral cervical spinal cord neurites prefer to grow on rostral diaphragm membranes, while caudal cervical neurites prefer caudal diaphragm membranes.
Nat Med, 2008 • January 1, 2008
The study demonstrates that significant recovery of hindlimb stepping can occur after severe spinal cord injury (SCI) in mice, even when direct connections from the brain to the legs are severed. This...
KEY FINDING: Pronounced functional recovery can occur after severe SCI without the maintenance or regeneration of direct projections from the brain past the lesion.
The Journal of Neuroscience, 2007 • December 26, 2007
The study investigates the expression pattern and function of Advillin, an actin-binding protein, in the developing mouse nervous system, focusing on its role in somatosensory neurons. Using a novel A...
KEY FINDING: Advillin mRNA is almost exclusively expressed by craniofacial and dorsal root ganglia sensory neurons, with the exception of Me5 and Mo5 neurons.
PNAS, 2008 • January 15, 2008
This study investigates the role of Nogo-66 receptor (NgR) in motor neuron survival, revealing that peptides derived from the Nogo-66 sequence, Pep4 and NEP1-40, can prevent p75NTR-dependent motor neu...
KEY FINDING: NgR, LINGO-1, and p75NTR mRNAs are expressed in cultures of purified embryonic motor neurons and NSC34 cells, indicating that NgR activation could involve p75NTR in this paradigm.
J Neurosci Methods, 2008 • March 30, 2008
The study introduces a novel in vivo imaging technique for the mouse spinal cord, addressing the challenge of movement artifacts caused by breathing and heartbeat. This technique uses a custom-built s...
KEY FINDING: A novel in vivo technique for two-photon microscopy was developed to allow direct, stable and repetitive imaging of densely populated cells and axons in the living spinal cord of transgenic mice.
BMC Neuroscience, 2008 • January 14, 2008
The study investigates the effect of anti-Nogo-A antibody treatment on cell body shrinkage in the motor cortex of monkeys after unilateral cervical cord lesion. The findings indicate that anti-Nogo-A ...
KEY FINDING: Unilateral cervical lesion does not lead to significant neuronal loss of corticospinal (CS) neurons in the contralesional hemisphere.
The Journal of Neuroscience, 2008 • January 16, 2008
The study examines the electrophysiological and molecular changes in reticulospinal (RS) neurons of larval lampreys following spinal cord injury, specifically focusing on the effects of axotomy on fir...
KEY FINDING: Axotomized RS neurons initially display altered firing patterns, including single short bursts or short repetitive bursts, in response to sustained depolarization.