The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse

This research paper focuses on the expression and function of peripherin, a type III neuronal intermediate filament, in the tuberomammillary (TM) neurons of the mouse hypothalamus. Peripherin is normally found in the peripheral nervous system and certain parts of the brain. The study found that peripherin is produced by histaminergic neurons in the TM nucleus. They used peripherin knockout and overexpressing mice to study how peripherin affects these neurons. Despite finding peripherin expression in TM neurons, the researchers did not observe significant differences in locomotor activity, feeding, drinking, or energy expenditure between mice with altered peripherin expression and control mice.

• 1
  Peripherin is expressed in the tuberomammillary neurons of the mouse hypothalamus, specifically within histaminergic neurons.
• 2
  Extensive colocalization of peripherin and histidine decarboxylase (HDC) was observed, indicating that peripherin is produced by histamine-producing neurons across the entire TM nucleus.
• 3
  No significant differences were found in locomotor activity, feeding, drinking, or energy expenditure between peripherin knockout, overexpressing, and wild-type mice, suggesting that the functional significance of peripherin in these neurons remains unclear.