Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,101-5,110 of 5,401 results
Frontiers in Aging Neuroscience, 2021 • March 8, 2021
This review summarizes the normal mechanism of mitochondrial quality control in axons, describes the behavior of mitochondria in axon degeneration under different conditions, and their role in axon re...
KEY FINDING: Aging is associated with mitochondrial transport, with changes in Mfn2 expression affecting mitochondrial morphology and transport in glaucoma.
Oxidative Medicine and Cellular Longevity, 2021 • March 15, 2021
This paper mainly describes the regulatory role of lncRNAs in various nervous systems and in neural differentiation of stem cells in various physiological or pathological processes. In general, more an...
KEY FINDING: lncRNAs are involved in the growth, development, and repair of the central and peripheral nervous systems.
International Journal of Molecular Sciences, 2021 • March 9, 2021
This study investigates the effects of montelukast (MTK), a leukotriene receptor antagonist, on neuroinflammation and cognition in 5xFAD mice, a model for Alzheimer's disease (AD). The results showed ...
KEY FINDING: MTK treatment modulated glial activation and neuroinflammation pathways in 5xFAD mice. The treatment increased Tmem119+ microglia and downregulated genes related to AD-associated microglia.
Frontiers in Neurology, 2021 • March 18, 2021
This study investigated the potential of long-term filgrastim treatment in a small cohort of ALS patients, using the PRO-ACT database as a historical control. The results suggest that filgrastim is sa...
KEY FINDING: Filgrastim-treated patients showed a significant survival benefit compared to the PRO-ACT database.
Frontiers in Molecular Neuroscience, 2021 • March 22, 2021
The editorial discusses the dysfunction and repair of neural circuits for motor control, focusing on how trauma, neurodegenerative diseases, and pathological conditions affect these circuits. The Rese...
KEY FINDING: Motor cortical areas initiate communication with spinal cord circuitry for voluntary movement, conveying commands via spinal motor neurons to skeletal muscles; sensory information is equally essential.
Front. Bioeng. Biotechnol., 2021 • March 22, 2021
This study investigates the use of PLA nanofibers functionalized with SDF-1α/CXCL12 to enhance the migration of TEG3 cells, an OEC-derived cell line, for neural regeneration therapy. The results demons...
KEY FINDING: PLA nanofibers with a diameter of 950 nm showed the best results for TEG3 cell adhesion and migration.
Frontiers in Cell and Developmental Biology, 2021 • March 25, 2021
This review explores the potential of ghrelin as a therapeutic molecule for nervous system injuries. Ghrelin's ability to cross the blood-brain barrier and influence multiple physiological processes m...
KEY FINDING: Ghrelin can modulate downstream signaling cascades in both the developing and adult nervous systems, influencing neurogenesis and neuronal plasticity.
Journal of Tissue Engineering, 2020 • November 21, 2020
This study investigates the combined effects of 7, 8-dihydroxyflavone (DHF) treatment and bone marrow-derived stem/stromal cells (BMSCs) engraftment into acellular nerve allografts (ANAs) for promotin...
KEY FINDING: 7, 8-DHF promotes the proliferation, survival, and Schwann-like cell differentiation of BMSCs in vitro by upregulating TrkB and ERK1/2 phosphorylation.
PNAS, 2000 • May 9, 2000
This study investigates how the brain reorganizes after a loss of sensory input from the arm in adult monkeys. The researchers found that nerve fibers from the face area of the brainstem grow into the...
KEY FINDING: After dorsal column lesions or arm amputation, face afferents from the trigeminal nucleus sprout and grow into the cuneate nucleus in adult monkeys.
PNAS, 2000 • July 5, 2000
The study investigates the physiological function of the kinin B1 receptor by generating mice with a targeted deletion of the B1 receptor gene. These mice are healthy and normotensive but show a blunt...
KEY FINDING: B1 receptor-deficient mice exhibited blunted hypotensive response to bacterial lipopolysaccharide.