Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,091-5,100 of 5,401 results
iScience, 2021 • February 19, 2021
The study identifies Neurod4 as a promising transcription factor for promoting neuroregeneration after spinal cord injury (SCI). Delivery of Neurod4 via a pseudotyped retroviral vector converts endoge...
KEY FINDING: Neurod4 promotes the conversion of ependymal cells to neural stem cells (NSCs) after spinal cord injury.
International Journal of Molecular Sciences, 2021 • February 11, 2021
Axon growth and regeneration are cellular processes that involve signaling from the growth cone, or the site of injury back to the cell body via signaling endosomes. The understanding of cellular orga...
KEY FINDING: The endoplasmic reticulum (ER) is crucial for lipid and protein synthesis, calcium homeostasis, and acts as a platform for signaling proteins important for growth and response to injury.
Brain Sci., 2021 • February 27, 2021
This systematic review synthesizes findings from studies using TMS–EEG co-registration in patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and other dementias. We aimed to revi...
KEY FINDING: TMS-EEG studies have identified a reduced TMS-evoked P30 response in AD patients, particularly in the temporo-parietal and fronto-central areas, indicating sensorimotor system rearrangement. The authors found in the AD patients a significantly decreased TMS-evoked P30 (time-locked response 30 ms after the TMS) in the temporo-parietal cortex ipsilateral to stimulation side and in the contralateral fronto-central area corresponding to the sensori-motor network
Frontiers in Immunology, 2021 • February 19, 2021
This study examined the impact of individual TnC fragments on astrocytic physiology in vitro and in vivo after spinal cord injury (SCI). The results indicated that TnC fragments delay gap closure in v...
KEY FINDING: TnC fragments delay gap closure in astrocyte cultures, primarily by reducing astrocyte proliferation. The most potent fragments were FnD, FnA, and their combination.
Theranostics, 2021 • February 20, 2021
This study investigates the role of SARM1 in spinal cord injury (SCI) using conditional knockout mice. The researchers found that SARM1 is upregulated in neurons and astrocytes after SCI, promoting ne...
KEY FINDING: SARM1 was upregulated in neurons and astrocytes at the early stage after SCI.
Cell Death & Disease, 2021 • March 26, 2021
This study investigates the therapeutic potential of neural stem cells (NSCs) modified with adeno-associated virus 2 (AAV2) to express basic fibroblast growth factor (bFGF) under the control of a hypo...
KEY FINDING: AAV2-5HRE-bFGF-NSCs treatment yielded temporally increased expression of bFGF in SCI.
Scientific Reports, 2021 • March 1, 2021
This study demonstrates that tacrine and duloxetine, L1 mimetic compounds, exhibit beneficial effects in the peripheral and central nervous system of demyelinated zebrafish. The observed benefits incl...
KEY FINDING: Tacrine and duloxetine promote the regeneration of oligodendrocytes in the central nervous system after oligodendrocyte ablation in zebrafish.
PLOS Genetics, 2021 • March 24, 2021
This study comprehensively characterized the temporal dynamic gene expression profile and epigenetic status during early cortical development, uncovering molecularly heterogeneous subpopulations withi...
KEY FINDING: Identified a new set of coding genes and lncRNAs involved in early neuronal differentiation and validated with functional assays in vitro and in vivo.
Journal of Neuroinflammation, 2021 • March 23, 2021
The study investigates the role of CRYAB, a small heat shock protein, in the immune response following peripheral nerve injury, focusing on macrophages. Results show that Cryab−/− mice exhibit a prolo...
KEY FINDING: More pro-inflammatory CD16/32+ macrophages are present in the nerves of Cryab−/− mice at days 14 and 21 after sciatic nerve crush-injury compared to WT counterparts.
Frontiers in Cellular Neuroscience, 2021 • March 8, 2021
The review summarizes the roles of endogenous estrogens, estrogen-based therapies, and estrogen-like molecules on brain homeostasis, especially regarding neurogenesis, gliogenesis, and neuroprotection...
KEY FINDING: Estrogens, including estradiol, promote survival in neurons subjected to stress conditions and may counteract aging-associated cognitive decline and prevent Alzheimer’s disease.