Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,111-5,120 of 5,401 results
Nat Biotechnol, 2000 • September 1, 2000
The study investigates the potential of xenotransplantation of genetically engineered pig cells, specifically olfactory ensheathing cells (OECs) and Schwann cells expressing the human complement inhib...
KEY FINDING: Transgenic pig OECs or Schwann cells transplantation restored impulse conduction across and beyond the lesion site in transected rat spinal cords.
PNAS, 2001 • May 8, 2001
BMP2 alters the fate of CNS neural precursor cells from neurogenesis to astrocytogenesis. This alteration is mediated by negative HLH proteins. The findings have potential clinical applications for mi...
KEY FINDING: BMP2 reduces the number of cells expressing neuronal markers (MAP2) and markers for undifferentiated neural precursors (nestin).
PNAS, 2001 • July 3, 2001
The study investigates the roles of BDNF and NT-4 in spinal cord sensory processing using knockout mice and an in vitro spinal cord preparation. Results show that BDNF, but not NT-4, is necessary for ...
KEY FINDING: BDNF-deficient mice showed reduced ventral root potential (VRP) evoked by stimulating nociceptive primary afferents, indicating impaired nociceptive transmission.
PNAS, 2001 • December 18, 2001
This study investigates the effect of posttraumatic immunization with a peptide derived from Nogo-A (p472) on recovery from spinal cord injury in rats. The study found that immunization with p472 redu...
KEY FINDING: Posttraumatic immunization with p472, a peptide derived from Nogo-A, substantially reduced neuronal degeneration and promoted recovery after incomplete spinal-cord contusion in rats.
J Comp Neurol, 2002 • February 11, 2002
This study quantitatively assesses the remyelination potential of transplanted Schwann cells in demyelinated rat spinal cords, considering factors like donor age and cell preparation. The research dem...
KEY FINDING: Schwann cells, regardless of donor age or preparation method, can induce remyelination in spinal cord lesions.
PNAS, 2002 • March 5, 2002
This study explores a novel approach to treating spinal cord injuries (SCI) by creating an implant that mimics the architecture of a healthy spinal cord. The implant consists of a polymer scaffold see...
KEY FINDING: Implantation of the scaffold-plus-cells promoted long-term improvement in function relative to a lesion-control group.
The Journal of Cell Biology, 2002 • October 14, 2002
This study investigates the role of Nogo-A, a neurite growth inhibitor, in peripheral nerve regeneration by expressing it in Schwann cells of transgenic mice. The key finding is that Nogo-A expression...
KEY FINDING: Expression of Nogo-A in Schwann cells significantly delays axonal regeneration in the denervated adult mouse sciatic nerve.
PNAS, 2005 • July 26, 2005
The study identifies ephrin-B3, a developmental axon guidance molecule, as a myelin-based inhibitor of neurite outgrowth in the adult spinal cord. Ephrin-B3 is expressed in myelinating oligodendrocyte...
KEY FINDING: Ephrin-B3 is expressed in postnatal myelinating oligodendrocytes in the mouse spinal cord, suggesting a role in myelin-based inhibition of axon outgrowth.
J Neurobiol, 2003 • January 8, 2003
This study examines the role of PDGF and FGF2 in regulating oligodendrocyte progenitor cell (OP) responses to demyelination using a murine hepatitis virus (MHV-A59) model in adult mice. The research d...
KEY FINDING: Endogenous PDGF and FGF2 stimulate the proliferation of OPs in cultures isolated during demyelination.
J Neurophysiol, 2003 • October 1, 2003
This study examines the expression and function of PACAP in the olfactory system of mice and rats, finding it present in olfactory epithelium and olfactory ensheathing cells. The study highlights diff...
KEY FINDING: PACAP immunoreactivity is present in the olfactory epithelium of neonatal, adult mice, and adult rats.