Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 251-260 of 5,401 results
Dev Neurobiol, 2014 • August 1, 2014
This study examined the expression patterns and levels of aPKC and Ryk in the lumbar spinal cord of SOD1 (G93A) mice, a model of ALS. The researchers found that aPKC was upregulated in motor neurons a...
KEY FINDING: aPKC expression was increased in motor neurons of the lumbar spinal cord in SOD1 (G93A) mice at different stages, and colocalized with SOD1 in motor neuron cell bodies and extracellular aggregates.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013 • July 17, 2013
This study aimed to determine if FK506 and NGF had a synergistic effect on the recovery of spinal cord functions in rats with acute spinal cord injury. The results demonstrated that the combined treat...
KEY FINDING: The combined treatment of FK506 and NGF significantly enhanced the expression of NF200 in rats with spinal cord injury.
PLoS ONE, 2013 • October 11, 2013
This study analyzed gene expression changes in the spinal cord after injury and transplantation of MSCs or OECs. Acute transplantation of MSCs and OECs induced early expression of genes related to cel...
KEY FINDING: MSC and OEC transplanted acutely after injury up-regulate genes related to tissue protection and regeneration.
Cell Transplant, 2015 • January 1, 2015
This study demonstrates that the transplantation of a SC bridge alone promotes brainstem axon regeneration. This study demonstrated that initially fluid bridges promote both a robust increase in the e...
KEY FINDING: Initially fluid bridges of SCs and Matrigel improved regeneration of brainstem axons across the rostral interface compared to pregelled bridges.
World J Stem Cells, 2013 • October 26, 2013
Pluripotent stem cells are hoped to be donor cells in transplantation in regenerative medicine. Somatic stem cells with the ability to differentiate in various species of cells have been used as donor...
KEY FINDING: Ectodermal stem cells and mesodermal (mesenchymal) stem cells potentially differentiate to neurons, while it seems that endodermal stem cells do not differentiate to neurons without dedifferentiation or induction to iPS cells.
BioMed Research International, 2013 • August 7, 2013
This review discusses the supportive roles of various ECM molecules in neurite outgrowth, while acknowledging that ECM molecules also impact synapse formation and neural stem cell migration. Novel dev...
KEY FINDING: Laminins promote axonal growth in both the developing and adult nervous systems, particularly in areas where regeneration occurs.
ASN NEURO, 2013 • November 11, 2013
Traumatic injury or disease of the spinal cord and brain elicits multiple cellular and biochemical reactions that together cause or are associated with neuropathology. Ligands that target PPARs (perox...
KEY FINDING: PPAR activation inhibits the expression of M1 genes in cells exposed to M1-type stimuli and enhances the expression of M2 markers in the presence of M2 stimuli.
BMC Neuroscience, 2013 • November 13, 2013
This study investigates the differential properties of canine olfactory ensheathing cells (OECs) from the olfactory bulb (OB-OECs) and mucosa (OM-OECs) compared to Schwann cells, focusing on their mig...
KEY FINDING: OB-OECs migrate significantly faster than OM-OECs and Schwann cells in a scratch wound assay.
Curr Opin Organ Transplant, 2013 • December 1, 2013
Schwann cell transplantation for spinal cord injury is in the early stages of clinical testing, following promising preclinical development. The FDA approved a Phase 1 safety and feasibility study bas...
KEY FINDING: Transplanted Schwann cells have shown reparative effects in the damaged spinal cord, supporting axonal sprouting and myelination.
Nature Communications, 2013 • November 12, 2013
This study investigates the role of chondroitin sulfate N-acetylgalactosaminyltransferase-1 (T1) in spinal cord injury recovery. The research demonstrates that T1 knockout mice exhibit superior recove...
KEY FINDING: T1KO mice exhibit significantly better recovery from spinal cord injury compared to wild-type and ChABC-treated mice, based on locomotor behaviors and histological analysis.