Neurology Research

KEY FINDING: GFAP–/–Vim–/– mice showed less removal of synaptic boutons from injured motoneurons compared to wild-type mice after axotomy.

KEY FINDING: Artemin transiently reversed tactile and thermal hypersensitivity following axotomy, ligation or crush injury.

KEY FINDING: Gabapentin and pregabalin are effective for managing chronic neuropathic pain post-SCI, with pregabalin also potentially reducing anxiety and sleep disturbances. Lamotrigine, valproate, and carbamazepine were found ineffective.

KEY FINDING: In healthy participants, coherence and power spectra features showed the highest classification accuracies, with support vector machines (SVM) being the best classification tool.

KEY FINDING: Immunological demyelination induces a robust macrophage/microglial cell activation.

KEY FINDING: Adrenomedullin treatment reduced the clinical severity and incidence of EAE, the appearance of inflammatory infiltrates in spinal cord and the subsequent demyelination and axonal damage.

KEY FINDING: The tissue-engineered neural scaffold promotes the formation of myelin-like structures in vitro by NSC-derived myelinating cells and SCs.

KEY FINDING: Chronic activation of innate immune responses, especially by microglia, is a common link among various neurodegenerative diseases, potentially leading to neurotoxic pathways and progressive degeneration.

KEY FINDING: Diminished axon growth potential correlates with histone 4 (H4) hypoacetylation in mature DRG neurons.

KEY FINDING: Downregulating PTEN promotes axon regeneration and neuroprotection following CNS trauma.