Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 241-250 of 5,401 results
PLoS ONE, 2013 • August 12, 2013
The study investigated spinal cord injuries in developing opossums at postnatal days 7 and 28 to understand neuronal circuit remodeling and locomotor recovery. P7-injured opossums showed axonal regrow...
KEY FINDING: P7-injured animals regrew supraspinal and propriospinal axons through the injury site and recovered near-normal coordinated overground locomotion with altered gait characteristics.
PLoS ONE, 2013 • August 12, 2013
The study explores the interaction between carbon nanotube scaffolds and immature spinal cord neurons in vitro. The central finding is that spinal neurons adherent to carbon nanotube substrates underg...
KEY FINDING: Spinal neurons cultured on carbon nanotubes exhibit a 37% reduction in membrane capacitance, suggesting a difference in soma size and/or neurite extension.
Journal of Pharmacology and Pharmacotherapeutics, 2013 • July 1, 2013
The study introduces a cost-effective customized impact device for creating experimental spinal cord injuries in rats, addressing the financial limitations faced by researchers in developing countries...
KEY FINDING: The customized impact device produced consistent lesion effects in rats, as evaluated by behavioral scoring methods.
PLoS ONE, 2013 • August 13, 2013
The administration of high doses of minocycline was deleterious for motor neuron survival. In addition, it inhibited microglial activation and impaired glial viability and migration. These data sugges...
KEY FINDING: Prolonged minocycline administration decreased the survival of motor neurons in the organotypic cultures.
PLoS ONE, 2013 • August 19, 2013
The study developed a neonatal mouse spinal cord compression (SCC) injury model to investigate adaptive plasticity and human stem cell integration after injury. The model allows for high-throughput as...
KEY FINDING: Dramatic degeneration of axons and synaptic contacts was evident within 24 hours of SCC, and loss of neurons in the injured segment was evident for at least a month thereafter.
PLoS ONE, 2013 • August 1, 2013
This study investigates the therapeutic potential of BMSC-conditioned medium (CM) in a rat model of spinal cord injury (SCI), focusing on its effects on secondary injury processes. In vitro experiment...
KEY FINDING: BMSC-conditioned medium (BMSC-CM) protects neurons from apoptosis in vitro, suggesting a neuroprotective effect.
The Journal of Neuroscience, 2013 • September 25, 2013
This study demonstrates that suppressing PTEN expression with shRNA promotes the regeneration of injured CST axons after SCI. The regenerating axons form anatomical synapses and interact with the extr...
KEY FINDING: Suppression of PTEN expression using shRNA promotes regeneration of injured corticospinal tract (CST) axons after spinal cord injury (SCI).
JOURNAL OF NEUROTRAUMA, 2014 • March 15, 2014
The study demonstrates the feasibility of using a regulatable L1 expression system in human embryonic stem cell-derived neural stem cells (H9NSCs) to improve cell-based therapy for spinal cord injury ...
KEY FINDING: Regulatable L1 expression system: The study successfully developed a nonviral doxycycline-inducible system to control L1 expression in human neural stem cells (H9NSCs).
BMC Neuroscience, 2013 • September 27, 2013
The study demonstrates that transplanting OEG and SCs in the sub-acute phase after spinal cord injury improves anatomical outcomes. This is achieved by increasing spared/regenerated supraspinal fibers...
KEY FINDING: Both OEG and SCs transplantation increased locomotion in rats with spinal cord injuries, as measured by open field tests.
Biomaterials, 2014 • January 1, 2014
This study reports the design of a bioactive aligned scaffold using co-assembly of epitope-bearing and unfunctionalized PA molecules for neuroregenerative applications. The effects of IKVAV and RGDS e...
KEY FINDING: The presentation of IKVAV epitopes enhanced neurite growth from neurons encapsulated in the scaffold, and the alignment of the scaffold guided these neurites along the direction of the nanofibers.