Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 211-220 of 5,401 results
N Biotechnol, 2013 • June 25, 2013
Optogenetics, particularly using channelrhodopsins, offers precise control over cellular activity via light, with potential therapeutic applications for neurological and retinal disorders. Channelrhod...
KEY FINDING: Optogenetic tools, particularly channelrhodopsins, can be used to control neural circuits and restore function in various tissues.
PLoS ONE, 2013 • May 7, 2013
The study investigates the effects of a snake venom-derived fibrin sealant on functional recovery, neuronal survival, synaptic plasticity, and glial reaction after ventral root reimplantation. The res...
KEY FINDING: Root reimplantation with fibrin sealant enhances motor recovery and improves neuronal survival.
EMBO Mol Med, 2013 • June 1, 2013
This study demonstrates that etifoxine, a clinically available TSPO ligand, exhibits neuroprotective and anti-inflammatory effects in a mouse model of multiple sclerosis (EAE). Etifoxine administratio...
KEY FINDING: Etifoxine attenuated EAE severity when administered before the development of clinical signs and improved symptomatic recovery when administered at the peak of the disease.
Iranian Red Crescent Medical Journal, 2013 • February 1, 2013
This study aimed to assess the therapeutic potential of cholinergic neuron-like cells (CNLs) derived from bone marrow stromal cells (BMSCs) in a rat model of spinal cord contusion. The results demonst...
KEY FINDING: Rats treated with CNLs showed a higher rate of improvement in motor function compared to those treated with BMSCs alone or the untreated group, as measured by the BBB test.
Journal of Visualized Experiments, 2013 • May 9, 2013
The study introduces a novel technique for creating controlled cervical spinal cord laceration injuries in mice. This method incorporates vertebral facet fixation for spine stabilization, enhanced spi...
KEY FINDING: The described method allows for a reproducible cervical spinal cord laceration injury in mice with an accuracy of ±0.01 mm in lesion depth.
Int. J. Mol. Sci., 2013 • May 24, 2013
The study explores using magnetized olfactory ensheathing cells (OECs) for treating spinal cord injuries. OECs are modified with magnetic nanoparticles (MNPs) to enable controlled migration via magnet...
KEY FINDING: Magnetized OECs survive well without showing stress-related cellular responses.
PLoS ONE, 2013 • May 27, 2013
The study provides a comparative analysis of prominin-1–positive progenitor cells across species, establishing a framework for further functional characterization in the context of regeneration. The r...
KEY FINDING: Prominin-1 expression is conserved in proliferative ventricular neurogenic cells across vertebrate species.
J Neuropathol Exp Neurol, 2013 • July 1, 2013
The study aimed to determine if brief electrical stimulation of transplanted embryonic ventral spinal cord cells could improve motoneuron survival, axon regeneration, muscle reinnervation, and functio...
KEY FINDING: Brief electrical stimulation at 1 Hz for 1 hour significantly increased the number of myelinated axons.
Brain, 2013 • July 1, 2013
This study investigates the role of neuregulin 1 (NRG1) in nerve repair following injury in adult mice by conditionally ablating NRG1. The researchers found that NRG1 is not required for maintaining t...
KEY FINDING: Loss of neuregulin 1 impairs remyelination after nerve crush, but does not affect Schwann cell proliferation associated with Wallerian degeneration or axon regeneration or the clearance of myelin debris by macrophages.
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
The study analyzes mRNA expression levels of p75NTR, Trk A, and caspase-9 in a rat model of spinal cord injury (SCI) at different time points and locations around the injury site. Results show a compl...
KEY FINDING: The expression of p75NTR, Trk A, and caspase-9 mRNA changes after SCI, with the greatest variation observed in the center regions of the injury.