Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 221-230 of 5,401 results
The Journal of Neuroscience, 2013 • July 3, 2013
The study used a multistep screening approach to discover genes specifically contributing to the regeneration-promoting properties of OECs. Microarray screening and functional characterization identif...
KEY FINDING: Sixteen genes in OECs (ADAMTS1, BM385941, FZD1, GFRA1, LEPRE1, NCAM1, NID2, NRP1, MSLN, RND1, S100A9, SCARB2, SERPINI1, SERPINF1, TGFB2, and VAV1) significantly reduced outgrowth of cocultured DRG neurons.
Neuroscience, 2013 • October 10, 2013
Ventral root avulsion injury in the rhesus macaque resulted in a marked loss of axotomized motoneurons and an astroglial reaction in the ventral horn. The avulsed ventral roots undergoing initial Wall...
KEY FINDING: A lumbosacral VRA injury resulted in retrograde motoneuron loss and astrocytic glial activation in the ventral horn.
Glia, 2013 • September 1, 2013
The study aimed to identify novel regulators of glial development using Aldh1l1-GFP as a marker for gliogenic radial glia and later-stage precursors of developing astrocytes. Gene expression profiling...
KEY FINDING: Aldh1l1 is a useful marker for identifying gliogenic lineages during embryonic spinal cord development.
Neurosci Bull, 2013 • August 1, 2013
The study investigated functional recovery and anatomical regeneration after spinal cord transection in rats at different developmental stages (PN1, PN7, PN14, and adult). Neonatal rats (PN1 and PN7) ...
KEY FINDING: Rats transected at PN1 and PN7 showed a significant level of stepping function after complete spinal cord transection, unlike PN14 and adult rats.
Neurosci Bull, 2013 • August 1, 2013
Successful axonal regeneration in the injured nervous system is a complex process that involves coordinated regulation of gene expression in the soma and cytoskeleton assembly at the growth cone. The ...
KEY FINDING: A large-scale RNAi-based genetic screen has identified dual leucine zipper-bearing kinase 1 (DLK-1) as a key regulator of axon regeneration
Clinical and Experimental Immunology, 2013 • January 1, 2013
This study investigates the neuroprotective effects of C5a after spinal cord injury (SCI). It examines the impact of C5a administration at different time points relative to the injury, both in vivo an...
KEY FINDING: Delayed administration of C5a (24 hours post-injury) significantly improved locomotor function in mice after SCI.
Neurosci Bull, 2013 • August 1, 2013
Glial scar formation after spinal cord injury involves complex molecular and cellular processes. It involves the misalignment of astrocytes and deposition of inhibitory molecules, impacting axonal re...
KEY FINDING: Glial scars are composed of fibrotic and glial tissues, with the glial scar mainly astrocytic, forming a physical barrier to axonal growth after SCI. The glial scar has increased expression of ECM components, predominantly secreted by reactive astrocytes.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013 • September 13, 2013
This study identifies a novel mechanism for promoting axonal sprouting and regeneration in the CNS in vivo: the targeting of LRP1 receptors. Agonists of this LDL gene family receptor result in activat...
KEY FINDING: LRP1 activation promotes neurite outgrowth from adult DRG sensory neurons under both permissive and non-permissive conditions.
Exp Eye Res, 2014 • June 1, 2014
This article reviews the mechanisms involved in neuronal regeneration in the adult zebrafish retina, focusing on the role of Müller glia. Retinal damage induces Müller glia to dedifferentiate and reen...
KEY FINDING: TNFα, a signaling molecule, is produced by dying retinal neurons and signals to Müller glia to initiate proliferation. Knockdown of TNFα expression significantly reduced Müller glial proliferation.
Molecular Therapy—Nucleic Acids, 2013 • July 23, 2013
The study demonstrates that AAV can be retrogradely transported by axons severed by SCI to transduce supraspinal neurons. Intraspinal injection of AAV near the injury site resulted in transduction of ...
KEY FINDING: AAV injected into the spinal cord near an injury site can travel to the brain and deliver genes to nerve cells.