Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 201-210 of 5,401 results
The Journal of Neuroscience, 2013 • March 27, 2013
The study demonstrates that a continuous growth-promoting pathway, constructed by grafting Schwann cells overexpressing GDNF within and caudal to a spinal cord injury, leads to anatomical regeneration...
KEY FINDING: Grafted Schwann cells overexpressing GDNF promoted regeneration of descending propriospinal (DPST) axons through and beyond the lesion gap of a spinal cord hemisection.
Nat Neurosci, 2013 • May 1, 2013
The study reveals extensive degeneration of gray matter oligodendrocytes in ALS mice before disease onset, with impaired maturation of newly formed oligodendrocytes leading to demyelination. Oligodend...
KEY FINDING: Extensive degeneration of gray matter oligodendrocytes occurs in the spinal cord of ALS mice before disease onset.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
The present results establish that electrical stimulation of embryonic neurons for 1 h immediately after transplantation increases neuron, motoneuron, and myelinated axon counts, resulting in long-ter...
KEY FINDING: Acute stimulation of the transplant increased the median number of NeuN-positive neurons after 10 weeks.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
This study demonstrates that blocking EphA4 activation with EphA4-Fc improves functional outcomes and promotes structural changes in a rat model of contusive spinal cord injury. The researchers found ...
KEY FINDING: EphA4-Fc treatment significantly improves locomotor function in rats after contusive spinal cord injury, as measured by the ledged tapered balance beam task and open-field testing.
Cell Death and Disease, 2013 • April 4, 2013
This study investigates the role of SHP-1, an intracellular protein tyrosine phosphatase, in axonal reorganization and functional recovery after brain injury. The researchers hypothesized that SHP-1 n...
KEY FINDING: SHP-1 expression and activity increase in the contralesional cortex (the side opposite the injury) after a unilateral motor cortex injury.
Journal of Visualized Experiments, 2013 • March 28, 2013
This article presents an experimental method to investigate the cellular responses to CNS injury in Drosophila larvae. The method involves inflicting a lesion on the larval VNC with a tungsten needle ...
KEY FINDING: Stabbing injury to the larval VNC results in a visible lesion that can be tracked over time using GFP markers, with the wound area initially expanding before shrinking.
Neuroscience, 2013 • August 15, 2013
Reticulospinal (RS) neurons are critical for initiation of locomotor behavior, and following spinal cord injury (SCI) in the lamprey, the axons of these neurons regenerate and restore locomotor behavi...
KEY FINDING: Activation of cAMP pathways with forskolin or dbcAMP stimulated neurite outgrowth of RS neurons in culture in a PKA-dependent manner.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
This study meticulously characterized the phenotypic diversity and plasticity of hGRP prepared by a Good Manufacturing Practice (GMP) production standard for possible clinical application. The study f...
KEY FINDING: hGRP and hGRP-derived astrocytes showed excellent survival and expressed astrocyte markers after transplantation into a spinal cord lesion.
PLoS ONE, 2013 • April 24, 2013
This study compares the potential of OECs from the olfactory bulb (OB-OECs) and olfactory mucosa (OM-OECs) for spinal cord repair after severe SCI. The results demonstrate that transplantation of OECs...
KEY FINDING: Transplantation of OECs from OB or OM induces electrophysiological and functional recovery after spinal cord injury.
Trends Neurosci, 2013 • June 1, 2013
CNS regeneration inhibitors, including Nogo-A, OMgp, and CSPGs, have novel functions in regulating dendritic spine maturation, synapse stability, and synaptic plasticity in the naïve CNS. These inhibi...
KEY FINDING: CNS regeneration inhibitors like Nogo-A and CSPGs promote dendritic spine maturation and stability, influencing neuronal structure in a cell-autonomous manner.