Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 211-220 of 278 results
Physiol Rep, 2018 • June 1, 2018
The study aimed to determine if spinal cord injury affects the intrinsic ability of satellite cells to differentiate and produce metabolically healthy myotubes. The results indicate that the intrinsic...
KEY FINDING: Satellite cells from spinal cord-injured individuals retain the capacity to differentiate into myotubes.
Calcif Tissue Int., 2018 • October 1, 2018
This preclinical study demonstrates that sclerostin antibody (Scl-Ab) can reverse sublesional bone loss in rats with chronic motor-complete spinal cord injury (SCI). Treatment with Scl-Ab restored bon...
KEY FINDING: Scl-Ab treatment significantly increased bone mineral density (BMD) at the distal femur, proximal tibia, and lumbar spine in rats with chronic SCI.
Spinal Cord Series and Cases, 2018 • July 15, 2018
This retrospective study analyzed hospital admissions in Iceland over a 5-year period to assess the epidemiology of traumatic spinal fractures (SFs) and associated spinal cord injuries (SCI). The stud...
KEY FINDING: Spinal fractures led to spinal cord injury in 9% of patients.
Spinal Cord Series and Cases, 2018 • June 17, 2018
This cross-sectional study aimed to understand the prevalence of fractures and musculoskeletal ailments in Norwegians with SCI more than 20 years post-injury. The study found high rates of fractures a...
KEY FINDING: Around half of the participants experienced a fracture after injury, highlighting a significant long-term risk.
Neural Regeneration Research, 2018 • October 1, 2018
This study validated a semi-automated threshold technique against manual tracing for measuring thigh muscle compartments in SCI patients, aiming for an accurate and faster tool. The threshold techniqu...
KEY FINDING: The threshold technique accurately measures thigh circumference, subcutaneous adipose tissue, whole muscle, femoral bone, bone marrow fat, knee extensor, and intramuscular fat cross-sectional areas in men with SCI.
PLoS ONE, 2018 • August 29, 2018
This study investigated the effects of ursolic acid (UA) on sub-lesional muscle pathology in a mouse model of spinal cord injury (SCI). The study found that UA improves anabolic IGF-1/mTOR signaling, ...
KEY FINDING: Ursolic acid treatment attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K.
Calcif Tissue Int, 2019 • January 1, 2019
This study characterized the time courses of cancellous and cortical bone deficits in a clinically relevant rodent SCI model to assist in identifying the mechanism exacerbating skeletal deterioration ...
KEY FINDING: SCI produced immediate sublesional paralysis and persistent hindlimb locomotor impairment in rats.
Osteoporos Int, 2018 • December 1, 2018
Computed tomography and finite element modelling were used to assess bone structure at the knee as a function of time after spinal cord injury. Analyzed regions experienced degradation in stiffness, m...
KEY FINDING: Bone degradation after SCI is well described by an exponential decay, reaching steady-state levels within 3.5 years.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This study compared DXA and MRI for assessing thigh skeletal muscle mass in individuals with spinal cord injury (SCI). The results showed a strong relationship between DXA and MRI measurements, sugges...
KEY FINDING: DXA measurements were strongly correlated with MRI measurements for whole thigh muscle mass, absolute muscle mass (excluding intramuscular fat), and knee extensor muscle mass.
JBMR® Plus, 2019 • May 1, 2019
This randomized clinical trial evaluated the impact of FES-rowing alone versus FES-rowing plus zoledronic acid (ZA) on bone density and geometry in individuals with chronic spinal cord injury (SCI). T...
KEY FINDING: Combination therapy (FES-rowing plus zoledronic acid) resulted in greater cortical bone volume (CBV) at the proximal tibial and distal femoral metaphyses compared to FES-rowing alone.