Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 201-210 of 278 results
Muscle Nerve, 2011 • January 1, 2011
This study investigated the molecular mechanisms underlying muscle stimulation training in individuals with spinal cord injury (SCI). Two SCI subjects who received >6 years of electrical stimulation t...
KEY FINDING: Long-term electrical stimulation training preserved torque, fatigue index, contractile speed, and cross-sectional area in the trained leg compared to the untrained leg.
Neurorehabil Neural Repair, 2011 • June 1, 2011
This study examined the effects of doublet train activation on paralyzed muscle before and after fatigue, and at different levels of potentiation. The doublet protocol enhanced peak muscle torque, mea...
KEY FINDING: Doublet stimulation significantly enhanced peak muscle torque, mean torque-time integral, and rate of torque development in chronically paralyzed soleus muscles.
J Bone Miner Res, 2012 • February 1, 2012
This study examined the relationship between circulating sclerostin levels and bone in subjects with chronic SCI, finding that sclerostin levels increase with age, consistent with previous research. A...
KEY FINDING: Greater total limb bone mineral content was significantly associated with greater circulating levels of sclerostin in subjects with SCI.
PLoS ONE, 2017 • August 30, 2017
This study explored the role of the peripheral nervous system in heterotopic ossification (HO) following spinal cord injury (SCI) using a mouse model. The researchers found that peripheral denervation...
KEY FINDING: Peripheral denervation increases heterotopic bone volume in mice with spinal cord injury and muscle damage.
The Journal of Spinal Cord Medicine, 2017 • January 1, 2017
The study evaluated the efficacy of FES-T assisted walking compared to conventional exercise on bone biomarkers and bone strength in adults with chronic motor incomplete SCI. Four months of FES-T impr...
KEY FINDING: Participants in the FES-T arm had a decrease in CTX and a significant increase in OC at intervention completion.
Scientific Reports, 2017 • September 20, 2017
The study demonstrates that skeletal muscle fibers release exosomes, extending previous research on exosomes from myoblasts and myotubes. These exosomes contain microRNAs and can be taken up by recipi...
KEY FINDING: Skeletal muscle fibers release exosomes containing proteins and miRNAs.
Medical Science Monitor, 2017 • November 12, 2017
This study investigated the relationship between a2-HS glycoprotein levels and neurogenic heterotopic ossification (NHO) in spinal cord injury (SCI) patients. The study found that decreased levels of ...
KEY FINDING: SCI patients with NHO exhibited significantly lower levels of a2-HS glycoprotein compared to those without NHO.
Osteoporos Int, 2012 • September 1, 2012
People with spinal cord injury (SCI) lose bone and muscle integrity after their injury. Early doses of stress, applied through electrically induced muscle contractions, preserved bone density at high-...
KEY FINDING: BMD for the High Dose group significantly exceeded BMD for both the Low Dose and the Untrained groups (p<0.05).
Top Spinal Cord Inj Rehabil, 2018 • June 12, 2017
This systematic review investigated the efficacy of NMES for increasing voluntary muscle strength in individuals with SCI. The review included five studies, with mixed results regarding the effectiven...
KEY FINDING: Two studies found that NMES increased strength, measured by peak force and manual muscle force test, after the NMES protocol.
PLoS ONE, 2018 • March 26, 2018
This study investigated the effects of pharmacologic sclerostin inhibition and testosterone administration on muscle atrophy in rats after spinal cord injury (SCI). Sclerostin inhibition did not preve...
KEY FINDING: Sclerostin antibody (Scl-Ab) did not prevent soleus muscle atrophy after spinal cord injury (SCI) in rats.