Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 101-110 of 278 results
J. Clin. Med., 2022 • June 29, 2022
The study investigated the reproducibility and accuracy of REMS for femoral BMD estimation and the discriminative power of the REMS-derived femoral fragility score in patients with primary and disuse-...
KEY FINDING: REMS demonstrated excellent test-retest reproducibility for estimating femoral neck BMD, total femur BMD, and the femoral fragility score in both patient groups.
Frontiers in Endocrinology, 2022 • August 5, 2022
This study evaluated the differential expression of miRNAs in subjects with chronic SCI, acute SCI, and no SCI to investigate the association of these miRNAs with SCI mediated osteoporosis and related...
KEY FINDING: MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI.
Top Spinal Cord Inj Rehabil, 2022 • July 1, 2022
The study compared the incidence of musculoskeletal (MSK) morbidities in adults with and without cerebral palsy (CP) or spina bifida (SB) using a large insurance claims database. Results showed that a...
KEY FINDING: Adults with CP or SB had a significantly higher incidence of any MSK morbidity (55.3% vs. 39.0%) compared to controls.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This scoping review examined the literature regarding methodologies to assess fracture risk, prevent and treat osteoporosis, and manage osteoporotic fractures in SCI/D patients. The review found that ...
KEY FINDING: Risk of osteoporotic fractures in SCI is predicted by a combination of DXA-defined low BMD plus clinical and demographic characteristics.
The Journal of Spinal Cord Medicine, 2020 • January 1, 2020
The study reviews historical literature on non-surgical management of thoracolumbar fracture dislocations, mainly involving bed rest and postural reduction, to compare with modern surgical outcomes. R...
KEY FINDING: Non-surgical management often resulted in residual spinal deformity and a high rate of post-treatment pain syndromes.
The Journal of Spinal Cord Medicine, 2020 • May 1, 2020
This study examined the impact of a functional electrical stimulation (FES) rowing program on bone mineral density (BMD) in individuals within two years of a spinal cord injury (SCI). The results sugg...
KEY FINDING: Trabecular BMD in the femur and tibia decreased for all participants in T0-1, but the rate of loss slowed or reversed between T1-2, with little-to-no bone loss for most participants during T2-3.
Spinal Cord, 2019 • July 15, 2019
This study investigated the association between bone turnover markers and fall-related fractures in 106 individuals with spinal cord injury (SCI) over a 1-year follow-up period. The primary finding wa...
KEY FINDING: High serum levels of carboxy terminal collagen crosslinks (CTX) increased the odds of being in the fracture group.
Physiological Reports, 2019 • October 1, 2019
This study compared the effects of abaloparatide and teriparatide on bone structure, turnover, and signaling pathways in mice and cells. The results showed that abaloparatide had a greater osteoanabol...
KEY FINDING: Abaloparatide caused a greater dose-dependent increase in cortical thickness than teriparatide.
The Journal of Spinal Cord Medicine, 2020 • October 1, 2020
This study aimed to identify T-score values at the total hip (TH) and femoral neck (FN) that correspond to the cutoff value of <0.60 g/cm2 for heightened risk of fracture at the distal femur (DF) and ...
KEY FINDING: aBMD at the DF and PT regions were significant predictors of T-score at the TH (R2 = 0.63, P < 0.001 and R2 = 0.65, P < 0.001) and FN (R2 = 0.55, P < 0.001 and R2 = 0.58, P < 0.001).
Spinal Cord, 2020 • March 1, 2020
This study demonstrates that rapid bone loss occurs as early as 2 days after a complete spinal cord injury (SCI) in rats. The researchers found a decrease in bone mass and deterioration of bone micros...
KEY FINDING: Neurologically motor-complete SCI causes loss of bone mass and deterioration of trabecular bone microstructure as early as 2 days after injury.