Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 91-100 of 278 results
International Journal of Molecular Sciences, 2022 • January 6, 2022
Spinal cord injury (SCI) leads to paralysis and a unique form of neurogenic disuse osteoporosis, heightening fracture risk at the distal femur and proximal tibia. The review identifies factors impacti...
KEY FINDING: Bone loss after SCI is distinct from other disuse conditions in both severity and mechanism.
BMC Musculoskeletal Disorders, 2022 • January 5, 2022
This cross-sectional study examined the relationships between physical activity, smoking status, body composition, muscle strength, and forearm bone mineral density (BMD) in adult men after spinal cor...
KEY FINDING: Active male smokers after SCI had significantly lower BMD dis, BMC dis and prox, T-score dis, and prox than male non-smokers after SCI.
Top Spinal Cord Inj Rehabil, 2022 • January 1, 2022
This retrospective study examined bone health changes in 79 children with AFM and found a high prevalence of low bone mass (78%) among those who had DXA scans. The study highlights the importance of m...
KEY FINDING: A significant percentage (78%) of children with AFM in the study were diagnosed with low bone mass.
Bone Research, 2022 • October 11, 2022
This study investigates the cellular origin of neurogenic heterotopic ossifications (NHOs), which frequently develop in muscles after spinal cord injuries (SCIs). Using lineage-tracing experiments in ...
KEY FINDING: NHOs developing after SCI in injured muscles in mice are not derived from muscle SCs. We also reveal that NHOs only develop in areas of the injured muscle where SCs fail to regenerate myofibers.
Spinal Cord Series and Cases, 2022 • February 20, 2022
This paper introduces a preliminary algorithm designed to mitigate fragility fracture risk during exoskeleton-assisted walking in individuals with chronic spinal cord injury, based on bone mineral den...
KEY FINDING: The developed algorithm classifies individuals into osteoporotic, osteopenic, and preserved bone mineral density profiles, assigning them to corresponding slow, moderate, and fast progression exoskeleton-assisted walking programs.
The Journal of Spinal Cord Medicine, 2023 • March 1, 2023
This retrospective study examined pathological fractures in Veterans with Spinal Cord Injury or Disorder (SCID) using administrative data from 2005-2015. The objective was to determine how often lower...
KEY FINDING: Approximately 2% of lower extremity fractures in Veterans with SCID were coded as pathological fractures.
Injury Epidemiology, 2022 • March 8, 2022
This study provides an overview of the extent of the issue and patient complexity necessary for planning the health-care management and injury prevention of CS-Fx. The typical CS-Fx patient was an eld...
KEY FINDING: The overall crude incidence rate of CS-Fx in Norway was 14.9/100,000 person-years.
Exp Physiol, 2022 • August 1, 2022
The investigation examined changes in the gene and protein expression of Notch, Numb, and Numb-like (Numbl) in human skeletal muscle after an acute bout of eccentric exercise-induced muscle damage. Th...
KEY FINDING: Notch1 mRNA expression trended toward a significant increase from Pre to 2 Days post-muscle damage from baseline measures (p = 0.087).
Spinal Cord Series and Cases, 2022 • May 6, 2022
The study investigated the impact of FES-assisted dynamic load-shifting exercises on bone mineral density (BMD) in individuals with complete spinal cord injury (SCI). The results indicated improvement...
KEY FINDING: Participants with acute and subacute SCI showed an absolute increase of trabecular vBMD (vBMDTRAB) in the proximal (mean of 26.9%) and distal tibia (mean of 22.35%).
Healthcare, 2022 • May 25, 2022
This prospective study investigated sclerostin levels and bone biomarker trends in patients with spinal cord injury (SCI). The study aimed to determine the serum concentration of sclerostin and factor...
KEY FINDING: Sclerostin levels significantly correlated with age, CTX level, and hip BMD in patients with SCI.