Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 461-470 of 730 results
Cell Death and Disease, 2021 • September 3, 2021
This study profiles transcriptomes and proteomes in a mouse model of AMI, revealing early immune system activation and pyroptosis. VX-765, a pyroptosis inhibitor, reduced infarct size and improved hea...
KEY FINDING: Immune system activation and subsequent pyroptosis occur in the early stages (6-24 hours) of AMI in a mouse model.
Journal of Neuroinflammation, 2021 • August 24, 2021
This study investigates the neuroprotective effects of tauroursodeoxycholic acid (TUDCA) in a mouse model of spinal cord injury (SCI). The results demonstrate that TUDCA treatment can alleviate second...
KEY FINDING: TUDCA reduces oxidative stress and protects cortical neurons in vitro, demonstrated by reduced ROS generation and LDH release.
The EMBO Journal, 2021 • September 29, 2021
This study investigates the role of DNA methylation in epidermal homeostasis by deleting Dnmt1 in mouse epidermis using Keratin 5-Cre (K5-Cre). The results show that DNMT1 ablation triggers a strong p...
KEY FINDING: Epidermis-specific deletion of DNMT1 disrupts epidermal structure and homeostasis, initiating a massive innate immune response and infiltration of immune cells.
Journal of Immunology Research, 2021 • September 24, 2021
This study investigates the impact of various stress conditions on the release of extracellular vesicles (EVs) by Trypanosoma cruzi trypomastigotes. The research examines how factors like temperature,...
KEY FINDING: Low temperatures (4°C) and acidic conditions (pH 5.0) increase EV release by Trypanosoma cruzi trypomastigotes.
Pharmacol Res Perspect, 2021 • May 1, 2021
Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. Dr. Michal Schwartz originally conceived the conce...
KEY FINDING: Deregulation of immune homeostasis may represent one of the key initial steps in NDD.
Neurol Neuroimmunol Neuroinflamm, 2021 • November 1, 2021
The study demonstrates that teriflunomide (TF) enhances oligodendroglial differentiation in vitro at nanomolar concentrations, both on neonatal and adult purified OPCs in cultures, an effect mediated by a...
KEY FINDING: Teriflunomide (TF) promotes the differentiation of neonatal and adult mouse oligodendrocytes at nanomolar concentrations.
Science, 2021 • November 12, 2021
The immune system is implicated in the neurodegenerative process of Lewy body dementia. T cells home to the LBD brain and reside in close proximity to α-synuclein deposits. In conclusion, these result...
KEY FINDING: T cells are located in close proximity to Lewy bodies and dopaminergic neurons in the brains of individuals with LBD.
J Immunother Cancer, 2021 • January 1, 2021
This study demonstrates the feasibility of redirecting pre-existing viral immunity against measles virus (MeV) to inhibit tumor growth in a preclinical model of aggressive squamous cell carcinoma. The...
KEY FINDING: MeV vaccination generated cytotoxic T lymphocyte (CTL) immunity in mice, demonstrated by enhanced interferon gamma production and antigen-specific T cell proliferation.
Cell Discovery, 2021 • January 1, 2021
This study comprehensively investigates pathophysiological and immunological changes in healthy volunteers after COVID-19 vaccination with an inactivated SARS-CoV-2 vaccine. The findings reveal consis...
KEY FINDING: Vaccination with an inactivated SARS-CoV-2 vaccine induces consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions.
Journal of Cellular Physiology, 2022 • March 1, 2022
The study investigates the effect of inflammatory stimuli and bile acids on myelin clearance by macrophages. Activation of the LPS-TLR4/NFκB pathway reduces myelin phagocytosis by bone marrow-derived ...
KEY FINDING: Activation of the TLR4-NFκB pathway reduced myelin uptake by bone marrow-derived macrophages (BMDM), while IFNγ-Jak/STAT1 signaling did not.