Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 931-940 of 1,773 results
Cells, 2021 • November 26, 2021
This study introduces a scalable workflow for purifying immunomodulatory AML-EVs and compares their phenotype and function to parental AML cells and secreted soluble factors. AML-EVs were enriched usi...
KEY FINDING: AML-EVs showed a significant dose-dependent inhibition of T cell proliferation, unlike AML cells or their soluble factors.
Exp Neurol, 2022 • April 1, 2022
This paper explores the potential of rAAV2-retro to deliver gene modifying cargoes to the cells of origin of multiple pathways that are interrupted by spinal cord injury (SCI), summarizing data from p...
KEY FINDING: rAAV-retro can simultaneously transduce large numbers of neurons of origin of multiple spinal pathways with single injections into the spinal cord.
BMC Genomics, 2022 • January 3, 2022
This study investigated DNA methylation changes in regenerative and non-regenerative regions of the Xenopus CNS after injury. The study found that DNA methylation patterns differ significantly between...
KEY FINDING: DNA from regenerative CNS (tadpole hindbrain, frog eye) was less methylated than non-regenerative CNS (frog hindbrain).
Oxidative Medicine and Cellular Longevity, 2022 • January 7, 2022
The review comprehensively covers the role of oxidative stress, inflammation, and apoptosis in the pathophysiology of SCI. It emphasizes the interconnectedness of these pathways and the need for multi...
KEY FINDING: Polyphenols can modulate neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in SCI.
Frontiers in Cell and Developmental Biology, 2021 • December 31, 2021
This study details the concentration-dependent effects of romidepsin on transcription and regeneration in axolotl embryos. It establishes a framework for investigating small molecule mechanisms of act...
KEY FINDING: Romidepsin inhibits axolotl embryo tail regeneration above a threshold concentration.
Frontiers in Cellular Neuroscience, 2022 • January 3, 2022
This study investigates the effectiveness of intralesional application of extracellular vesicles (EVs) in improving functional recovery in a rat model of traumatic spinal cord injury (tSCI). The resul...
KEY FINDING: Intralesional application of EVs resulted in a more robust improvement of motor recovery, assessed with the BBB score and sub-score, as compared to the intravenous delivery.
Journal of Clinical Orthopaedics and Trauma, 2022 • January 4, 2022
The Wnt/mTOR signaling pathway is a ubiquitous signaling cascade involved in various physiological and pathological processes, including those related to spinal cord injury (SCI). It plays a crucial r...
KEY FINDING: Wnt signaling plays an important role in SCI, regulating neural stem cell proliferation and differentiation, axon regeneration, neuroinflammation, and pain.
Stem Cell Research & Therapy, 2022 • January 1, 2022
This study investigates the role of Sin3a in somatic cell reprogramming, focusing on its interaction with Tet1 during the mesenchymal-to-epithelial transition (MET). The findings reveal that Sin3a coo...
KEY FINDING: Sin3a expression increases during MEF reprogramming and its knockdown impairs MET and iPSC generation.
Cell Calcium, 2022 • March 1, 2022
This study demonstrates that Erk1/2 activation in neural and muscle stem cells in response to injury is necessary for cell proliferation and regeneration of spinal cord and skeletal muscle in Xenopus ...
KEY FINDING: Erk1/2 signaling is activated in neural and muscle stem cells of regenerating tissues and is necessary for the regeneration of both spinal cord and muscle.
Frontiers in Pharmacology, 2022 • January 10, 2022
Recombinant adenoviruses (rAdVs) are commonly used vectors in gene therapy for spinal cord injury (SCI) due to their ability to transduce various cell types and provide high transgene expression. The ...
KEY FINDING: rAdV5-based vectors allow transduction of both nerve and glial cells, providing a high level of transgene expression.