Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective

Mitochondria, the energy centers of cells, participate in epigenetic regulation of neurodegenerative diseases. Mitochondria can influence nuclear epigenome using metabolites like acetyl-CoA and NAD+. Abnormal modification of mitochondrial DNA contributes to disease development via mitochondrial dysfunction.

• 1
  Nuclear epigenome affects mitochondrial function, influencing diseases like Alzheimer’s, Parkinson’s, Huntington’s, and ALS.
• 2
  Mitochondrial DNA methylation levels change dynamically with the development of AD, PD, and ALS.
• 3
  Non-coding RNAs regulate mitochondrial function, influencing the progression or treatment of neurodegenerative diseases.