Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 861-870 of 1,773 results
Neural Regen Res, 2021 • April 23, 2021
This study demonstrates that Id2 can accelerate axonal regeneration, promote neuromuscular reinnervation, and enhance functional improvement following sciatic nerve injury in mice. The researchers use...
KEY FINDING: Id2 was successfully delivered into spinal cord motor neurons projecting to the sciatic nerve.
Neural Regeneration Research, 2021 • December 1, 2021
This study investigates the interaction between spastin and CRMP3 in spinal cord injury repair, finding that CRMP3 expression is inversely associated with SCI severity. The research demonstrates that ...
KEY FINDING: Mass spectrometry identified the role of CRMP3 in the spinal cord injury repair process.
PLoS Genetics, 2021 • April 29, 2021
The study establishes an efficient sCrRNA screening paradigm that involves a pre-screening step to compensate for inherent variability in sCrRNA activity and to identify highly active guides (haCRs) f...
KEY FINDING: Rapid screening method identifies genes necessary for nerve connection repair and inflammation control after spinal cord injury in zebrafish.
Molecules, 2021 • April 1, 2021
The study investigated the roles of GAL2-R and GAL3-R in learning, memory, and anxiety in young and aging mice. Knockout mice lacking either receptor were subjected to behavioral tests and analyses of...
KEY FINDING: Loss of GAL3-R, but not GAL2-R, slowed learning and induced anxiety in older (12–14-month-old) mice.
International Journal of Molecular Sciences, 2021 • April 9, 2021
This study demonstrates that both cell culture oxygen conditions and the mode of EV preparation significantly affect the function of human iPSC-EVs. Hypoxic conditioning of human iPSCs resulted in the...
KEY FINDING: iPSC-EVs derived from 1% oxygen culture exhibit significantly elevated angiogenic potential compared to EVs obtained at higher oxygen levels.
Cells, 2021 • April 10, 2021
This study demonstrates that hair-follicle-associated pluripotent (HAP) stem cells can be efficiently differentiated into dopaminergic neurons in vitro. These HAP stem cell-derived dopaminergic neuron...
KEY FINDING: Mouse HAP stem cells can efficiently differentiate into dopaminergic neurons when cultured in neural-induction medium.
J Cell Mol Med, 2021 • May 1, 2021
This study investigates the effects of Wnt5a overexpression in a rat model of spinal cord injury (SCI). Wnt5a is a protein known to influence nerve growth and has been implicated in SCI pathology. The...
KEY FINDING: Wnt5a overexpression reduces neuronal cell density in spinal cord levels adjacent to the lesion epicentre.
eLife, 2021 • May 6, 2021
The study demonstrates that Hh signaling is necessary for regeneration of muscle and spinal cord in Xenopus larvae. Hh-Smo signaling is particularly important for NSC proliferation with regards to spi...
KEY FINDING: Smoothened (Smo) activity is essential for spinal cord and skeletal muscle regeneration in Xenopus laevis larvae.
四川大学学报（医学版）, 2021 • May 1, 2021
This review discusses the knowledge of exosomes and the research progress in the regeneration and repair of related connective tissues, including the regeneration of bones, cartilage, skin, spinal cor...
KEY FINDING: MSC-EXO具有促进软骨细胞的基质再生、加速软骨形成的作用.
Glia, 2021 • September 1, 2021
This study investigates the potential of hypoxia-mimetics, specifically deferoxamine (DFO) and adaptaquin (AQ), to protect Schwann cells (SCs) against oxidative stress-induced cell death, a significan...
KEY FINDING: Hypoxia-mimetics DFO and AQ enhance HIF-1α stability and HIF-1α target gene expression in Schwann cells.