Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 871-880 of 1,773 results
Advanced Science, 2021 • May 29, 2021
The study introduces a 3D fiber-hydrogel scaffold for non-viral delivery of microRNAs (miRs) to treat spinal cord injuries (SCI). Treatment with Axon miRs (miR-132/miR-222/miR-431) significantly enhan...
KEY FINDING: Axon miRs treatment, along with an anti-inflammatory drug, significantly enhances axon regeneration and functional recovery after spinal cord injury.
Cells, 2021 • May 1, 2021
We have discussed evidence suggesting that reprogramming lipid metabolism, boosting mitochondrial transport and neuron-glia metabolic coupling promote survival and regeneration of injured axons. Not o...
KEY FINDING: Neuronal depletion of lipin 1 promotes axon regeneration after optic nerve injury in mice by regulating glycerolipid metabolism and, more specifically, triglyceride hydrolysis and phospholipid synthesis.
Cells, 2021 • May 25, 2021
This study investigated the effect of macrophage-derived inflammation priming on mesenchymal stromal cells (MSCs) for spinal cord injury repair in a rat model. The researchers compared primed MSCs (pM...
KEY FINDING: Inflammatory priming reduces the long-term survival of MSC transplants in the contused spinal cord environment.
Cells, 2021 • May 28, 2021
This review discusses the potential of harnessing astrocytes and Müller glial cells in the retina to promote the survival and regeneration of retinal ganglion cells (RGCs). It draws parallels with stu...
KEY FINDING: Astrocytes and Müller cells in the retina undergo reactive gliosis after damage, and their role in RGC survival and axon regeneration is debated.
International Journal of Molecular Sciences, 2021 • May 27, 2021
This study investigates the role of PSA-NCAM in the development of immature neurons in the piriform cortex (PCX) of adult mice. Using a transgenic mouse model, the researchers removed PSA from NCAM in...
KEY FINDING: Enzymatic depletion of PSA in the piriform cortex of adult mice promotes the final stages of development of immature neuronal populations.
Curr Biol, 2021 • July 26, 2021
The study elucidates an injury-induced AKT-PAK5-SNPH signaling axis that maintains axonal energy supply after acute injury-ischemia in mature neurons and adult brains. Reprogramming PAK5 signaling rem...
KEY FINDING: Axonal PAK5 synthesis and signaling are activated in response to ischemia and injury, promoting neuron survival.
Frontiers in Molecular Neuroscience, 2021 • May 20, 2021
This study established an in vitro model of microglial activation using a spinal cord injury (SCI) lysate to mimic the post-injury environment. The SCI lysate induced morphological changes, proliferat...
KEY FINDING: SCI lysate stimulation leads to upregulation of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and downregulation of anti-inflammatory cytokines (IL-10 and IL-4) in microglia.
STAR Protocols, 2021 • June 18, 2021
The study describes a protocol for genome-scale CRISPR screening in genetically engineered human pluripotent stem cells (hPSCs) using the PAX6 reporter and an inducible CRISPR/Cas9 knockout system. Th...
KEY FINDING: The protocol allows for the identification of genes that prevent lineage specification, termed Lineage Specification Preventing Genes (LPGs).
Neural Regeneration Research, 2022 • January 1, 2022
This study investigated the role of lncRNA Vof-16 in spinal cord injury (SCI) by constructing knockdown and overexpression lentiviral vectors and transplanting them into PC12 cells and SCI model rats....
KEY FINDING: LncRNA Vof-16 overexpression decreases neuronal viability, proliferation, migration and neurite extension in vitro, whereas lncRNA Vof-16 knockdown has the opposite effects.
J Extracell Vesicles, 2021 • April 22, 2021
This study presents the first-in-human application of allogeneic UC-MSC-EVs during cochlear implantation, aiming to reduce inflammation and improve outcomes. A patient with Menière’s disease received ...
KEY FINDING: The intracochlear application of allogeneic UC-MSC-EVs during cochlear implantation appeared safe, with no acute systemic or local toxicity observed within the 5-day observation period and during the 24-month follow-up.