Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 791-800 of 1,773 results
CNS Neurosci Ther, 2017 • June 1, 2017
This study aimed to investigate the effects of overexpressing Olig2, a transcription factor involved in myelination, on adult spinal cord injury rats using lentivirus-mediated gene transfer. The resul...
KEY FINDING: Local injection of Lenti-Olig2 significantly increased the number of oligodendrocytes lineage cells and enhanced myelination after SCI.
J. Biol. Chem., 2017 • May 2, 2017
This study investigates how muscle-released products interact with bone cells to influence their function, focusing on myostatin's role in muscle-bone interaction. Myostatin directly targets osteocyte...
KEY FINDING: Myostatin increases the expression of SOST, DKK1, and RANKL in osteocytes, which are important regulators in bone remodeling.
Spinal Cord Series and Cases, 2017 • May 11, 2017
This study examined the effects of a wheelchair half marathon on adrenaline, oxidant/antioxidant balance, and oxLDL levels in athletes with cervical (CSCI) and lower (LSCI) spinal cord injuries. The r...
KEY FINDING: OxLDL levels remained stable throughout the study in both LSCI and CSCI subjects, despite adrenaline levels increasing in LSCI athletes after the half marathon.
Frontiers in Physiology, 2012 • October 10, 2012
The present review discusses the features of spinal cord plasticity with a specific emphasis on protecting against maladaptive plasticity in nociceptive systems and promoting adaptive forms of spinal p...
KEY FINDING: Spinal synapses can be strengthened or weakened in response to external stimulation, demonstrating the basic properties required for use-dependent learning and memory.
Neurobiol Dis, 2007 • June 1, 2007
This study investigates the role of spinal microglia in the anti-allodynic and anti-hyperalgesic effects of electroacupuncture (EA) in a rat model of monoarthritis induced by Complete Freund’s Adjuvan...
KEY FINDING: Unilateral intra-articular injection of CFA produced a robust microglial activation and the up-regulation of the tumor necrosis factor (TNF)-α, interleukin (IL-1β), and IL-6 mRNA levels in the spinal cord.
Mediators of Inflammation, 2017 • May 10, 2017
This study investigates the effects of methylprednisolone (MP) on edema and aquaporin 4 (AQP4) expression in rats following spinal cord injury (SCI). The results indicate that MP, contrary to its inte...
KEY FINDING: SCI increased AQP4 expression in the spinal cord white matter, and MP diminished this increase to baseline levels.
Pain, 2008 • July 31, 2008
This study investigated the role of TNF signaling in the development of CRPS-like changes in rats after tibia fracture. The researchers found that TNF expression was upregulated in the hindpaw skin an...
KEY FINDING: Tibia fracture upregulated TNF expression and protein levels in the hindpaw skin and sciatic nerve.
The Journal of Cell Biology, 2017 • August 7, 2017
Understanding how the transcription factor signal transducer and activator of transcription–3 (STAT3) controls glial scar formation may have important clinical implications. We show that astrocytic ST...
KEY FINDING: Astrocytic STAT3 is associated with greater amounts of secreted MMP2, a crucial protease in scar formation.
Exp Neurol, 2022 • August 1, 2022
Spinal cord injury (SCI) is a devastating event that can permanently disrupt multiple modalities. Unfortunately, the combination of the inhibitory environment at a central nervous system (CNS) injury ...
KEY FINDING: Adeno-associated virus (AAV) is a common vector of choice for gene therapy. Its low immunogenicity and risk of insertional mutagenesis combined with the ability to transduce both, dividing and non-dividing cells, make it an attractive option for researchers
Physiol Rep, 2014 • February 1, 2014
This study demonstrated that a low force single twitch stimulation protocol fatigued the human chronically paralyzed muscle. The fatigue index, the potentiation index, and speed properties responded i...
KEY FINDING: Low force stimulation (3 Hz) caused fatigue in chronically paralyzed quadriceps muscles of people with SCI, while the quadriceps of people without paralysis were not fatigued.