Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 781-790 of 1,773 results
Glia, 2016 • June 1, 2016
This study investigates the protective effects of adrenergic receptor agonists, specifically epinephrine (EPI) and isoprenaline (ISO), on cellular edema induced by hypotonicity and neurotrauma in cort...
KEY FINDING: Epinephrine administration reduces hypotonicity-induced swelling of astrocytes both in vivo and in vitro.
Scientific Reports, 2016 • March 11, 2016
This study elucidates the role of miR-434-3p in regulating eIF5A1 expression and AChRs formation in a rat model of spinal cord transection (SCT). The findings demonstrate that miR-434-3p acts as a neg...
KEY FINDING: miR-434-3p directly targets eIF5A1 to negatively regulate its expression in rat skeletal muscle.
PLoS ONE, 2017 • January 25, 2017
This study investigates the role of PAR-1 in wound healing and locomotor recovery after spinal cord injury. The research demonstrates a detrimental role for thrombin-activated PAR-1 in the healing pro...
KEY FINDING: PAR-1 null mice showed reduced neutrophil infiltration and improved vascular integrity after spinal cord injury compared to wild-type mice.
International Journal of Molecular Sciences, 2017 • January 25, 2017
This study examined the long-term effects of iNOS ablation in mice after spinal cord injury (SCI). The findings suggest that while acute iNOS inhibition may be beneficial, long-term ablation can be de...
KEY FINDING: iNOS−/− mice exhibited less preserved white and gray matter at six weeks post-SCI compared to wild-type controls.
Physiol Rep, 2017 • February 1, 2017
This study investigated the relationship between body composition and mitochondrial mass and activity in skeletal muscle biopsies from individuals with SCI. The study found that increased adipose tiss...
KEY FINDING: Citrate synthase (CS) activity, a marker of mitochondrial mass, was inversely related to %body fat, %leg fat, %trunk fat, and %android fat.
International Journal of Molecular Sciences, 2017 • February 27, 2017
This study investigated the effects of transplanting embryonic spinal cord-derived cells into injured peripheral nerves to prevent muscle atrophy. Both fetal cells (P0) and neural progenitor cells (P2...
KEY FINDING: Both fetal spinal cord cells (P0) and neural progenitor cells (P2) were able to survive in the injured peripheral nerve environment.
Scientific Reports, 2018 • August 10, 2018
This study evaluated the long-term efficacy and safety of aFGF in treating chronic SCI patients over a 48-month period. The aFGF was administered directly to the injured spinal cord during surgery and...
KEY FINDING: Significant improvements were observed in ASIA impairment scales, motor scores, pin prick, light touch, and FIM motor subtotal scores in both cervical and thoracolumbar SCI groups.
PLoS ONE, 2017 • March 27, 2017
The study found that loss of functional sympathetic innervation to the liver and VAT appears to favorably impact circulating TG concentrations and concentrations of total and specific subclasses of VL...
KEY FINDING: Men with SCI at or above the 4th thoracic vertebrae (T4), indicating more extensive sympathetic nervous system impairment, had significantly lower serum triglyceride (TG) concentrations compared to those with SCI at or below the 5th thoracic vertebrae (T5) and able-bodied (AB) subjects.
PLoS ONE, 2017 • March 30, 2017
The study identified clusters of adherent cells in short-term cultures from amniotic fluid cells of MMC-AF samples, which were phenotypically reminiscent of early neuroepithelium and absent in norm-AF...
KEY FINDING: A population of cells from the amniotic fluid of MMC fetuses (MMC-AF) formed adherent clusters of tightly packed cells, which were absent from the AF of normal control fetuses (norm-AF).
Journal of Extracellular Vesicles, 2025 • January 1, 2025
The study investigates the therapeutic potential of intranasally administered BDNF-loaded small extracellular vesicles (BDNF-sEVs) for acute spinal cord injury (SCI) in rats and monkeys. Results demon...
KEY FINDING: BDNF loading enhances the neurite outgrowth promoted by sEVs in cultured neurons, suggesting an improved neurotrophic effect.