Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 771-780 of 1,773 results
Cell Mol Neurobiol, 2015 • March 29, 2015
This study demonstrates that PQQ pretreatment has a protective effect in a rat model of intracerebral hemorrhage (ICH). The protective effects of PQQ include improved locomotor function, reduced hemat...
KEY FINDING: PQQ pretreatment improved locomotor function in rats after ICH, as evidenced by neurobehavioral deficit scoring.
Int. J. Mol. Sci., 2015 • April 9, 2015
This study measured serum cytokine levels in 40 acute traumatic SCI patients over 12 weeks to assess their impact on neurological outcome. The study found that specific cytokines (TNFα, IL-1β, IL-6, I...
KEY FINDING: TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission.
J Muscle Res Cell Motil, 2015 • October 1, 2015
This review focuses on the role of focal adhesion kinase (FAK), a prominent and well-studied protein that responds to changes in cellular tension. FAK has multiple roles within skeletal muscle, includ...
KEY FINDING: Changes in FAK expression and phosphorylation correlate with myoblast differentiation, muscle fiber formation, and muscle size changes due to loading and unloading.
JOURNAL OF NEUROTRAUMA, 2017 • March 15, 2017
The study investigates the role of RNA-binding protein HuR in the inflammatory response following spinal cord injury (SCI). The research demonstrates that HuR is translocated to the cytoplasm in astro...
KEY FINDING: HuR translocates to the cytoplasm of astrocytes at the site of spinal cord injury, indicating its activation in response to the trauma.
Scientific Reports, 2015 • July 30, 2015
This study investigates the molecular mechanisms behind post-SCI spasticity, focusing on the role of mRNA editing and ADAR2. The research demonstrates that SCI-induced inflammation leads to down-regul...
KEY FINDING: SCI leads to a decrease in mRNA editing of 5-HT2CR, specifically at site D, and Kv1.1 channel due to down-regulation of ADAR2 expression.
Neurobiol Dis., 2015 • November 1, 2015
This study investigates the role of Protease Activated Receptor 2 (PAR2) in inflammatory astrogliosis following spinal cord injury (SCI). The results demonstrate that mice lacking the PAR2 gene exhibi...
KEY FINDING: Mice lacking the PAR2 gene showed greater improvements in motor coordination and strength after spinal cord injury compared to wild type littermates.
PLOS ONE, 2015 • September 11, 2015
This study investigates the anti-inflammatory role of IL-27 in zymosan-induced peritonitis, focusing on its effects on neutrophil recruitment. The results demonstrate that IL-27 reduces neutrophil acc...
KEY FINDING: IL-27 treatment reduces neutrophil accumulation in the peritoneal cavity in a zymosan-induced peritonitis model.
Physiol Rep, 2015 • November 1, 2015
The study examined the expression of microRNAs and myostatin in skeletal muscle of humans with spinal cord injury. It found a progressive decline in microRNA-208b and microRNA-499-5p expression after ...
KEY FINDING: Skeletal muscle expression of microRNA-208b and microRNA-499-5p progressively declined within the first year after cervical spinal cord injury in humans, with changes maintained in long-standing injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2015 • May 21, 2015
This study investigates the antioxidative effects of Gua Lou Gui Zhi decoction (GLGZD) on hydrogen peroxide (H2O2)-induced oxidative stress in rat pheochromocytoma cells (PC12 cells). The results demo...
KEY FINDING: GLGZD pretreatment alleviates H2O2-induced damage in PC12 cells, as evidenced by morphological observations and increased cell viability.
Oxidative Medicine and Cellular Longevity, 2016 • January 1, 2016
The study revealed that SCI induces an increase in HDAC6 expression in vivo. This upregulation suggests a potential role for HDAC6 in the cellular response to SCI. In vitro experiments demonstrated th...
KEY FINDING: SCI increases HDAC6 expression in vivo.