Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 741-750 of 1,773 results
Glia, 2021 • May 1, 2021
This study investigates the heterogeneity of astrocyte subtypes in different brain regions and their response to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. The re...
KEY FINDING: Astrocytes exhibit significant regional heterogeneity, with distinct gene expression profiles depending on their location in the forebrain, hindbrain, or spinal cord.
Biological Reviews, 2021 • December 17, 2020
This review discusses the cells and molecules involved in establishing a regenerative niche at the neuromuscular junction (NMJ) to promote motor function recovery after injury. It emphasizes the impor...
KEY FINDING: A regenerative niche at the mature NMJ must ensure the arrival of regenerating axons to denervated postsynaptic muscle domains for reinnervation.
Molecular Oncology, 2021 • January 24, 2021
This study benchmarks HLA genotyping on TCGA data using multiple tools to generate reliable HLA genotyping results. It finds that HLA class I genotyping is generally better than class II genotyping, w...
KEY FINDING: POLY-SOLVER, OptiType, and xHLA show high accuracy in HLA class I genotyping, with accuracies of 0.954, 0.949, and 0.937, respectively.
mBio, 2021 • April 27, 2021
This study identifies HMGB1 as an architectural factor in Plasmodium falciparum, crucial for maintaining genome organization. HMGB1 is found to be enriched in centromeric regions and its loss leads to...
KEY FINDING: HMGB1 is primarily located in the centromeric regions of Plasmodium falciparum chromosomes.
Neurospine, 2021 • June 1, 2021
Spinal cord injuries present with a complex series of molecular cascades that ultimately induce cell death of neurons and glia and excitotoxicity of astrocytes, limiting the effect of therapeutic inte...
KEY FINDING: RIPK1 exhibits pleiotropic effects contributing to the exacerbation of SCI and sufficient evidence supports the therapeutic utility of RIPK1 inhibitors.
Trends Neurosci., 2021 • June 1, 2021
Extracellular vesicles (EVs) play significant roles in the central nervous system (CNS), mediating both physiological and pathophysiological processes, especially after neurotrauma like spinal cord in...
KEY FINDING: EVs have functional roles in mediating neuro-glia and CNS-periphery communication after neurotrauma by regulating neuronal function, axonal regeneration and remyelination, metabolic activity, and the inflammatory milieu.
Cellular and Molecular Neurobiology, 2022 • February 17, 2021
This study investigates the role of EphA4 in regulating astrocyte function and its impact on neuronal regeneration after spinal cord injury (SCI). The research identifies that EphA4 expression increas...
KEY FINDING: EphA4 expression significantly increases after spinal cord injury, peaking at 3 days post-injury.
Bioactive Materials, 2021 • January 24, 2021
The study introduces a novel therapeutic approach for spinal cord injury (SCI) using a bioactive, injectable, self-healing, and anti-inflammatory hydrogel (FE@EVs) designed for the sustained release o...
KEY FINDING: The FE@EVs hydrogel effectively encapsulates and releases extracellular vesicles in the injured spinal cord, facilitating efficient integrated regulation.
JCI Insight, 2021 • April 8, 2021
This study identifies Itga7-expressing muscle-resident glial cells that are activated by loss of neuromuscular junction (NMJ) integrity. Upon activation, muscle glial–derived progenies expressed neuro...
KEY FINDING: Muscle-resident glial cells, identified by Itga7 expression, are activated by nerve injury and express neurotrophic genes like Ngfr, Tnc and Gdnf.
G3, 2021 • March 20, 2021
The study combines high-efficiency CRISPR/Cas9 mutagenesis with functional phenotypic screening to identify genes required for spinal cord repair in adult zebrafish. Seventeen genes were targeted, and...
KEY FINDING: CRISPR/Cas9 dual-guide ribonucleic proteins (dgRNPs) can achieve selective and combinatorial mutagenesis of 17 genes at 28 target sites with efficiencies exceeding 85% in adult F0 crispants.