Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 731-740 of 1,773 results
Medical Science Monitor, 2015 • August 28, 2015
The article hypothesizes that miR-142-3p is the upstream molecular basis for sciatic nerve transection enhancing central regeneration of primary sensory neurons, and that it is a potential therapeutic...
KEY FINDING: miR-142-3p can induce cAMP elevation via adenylyl cyclase 9 (AC9), which is abundant in dorsal root ganglia (DRG).
Neural Regeneration Research, 2015 • July 1, 2015
This study investigates the expression of miR-124 after spinal cord injury in mice using in situ hybridization and quantitative RT-PCR. The findings indicate that miR-124 expression is significantly r...
KEY FINDING: miR-124 is mainly expressed in neurons throughout the brain and spinal cord of mice.
Neuroscience, 2015 • November 12, 2015
The study examines the expression and function of PTPRD in oligodendrocyte myelination. PTPRD is expressed in mature neurons early in development and later in oligodendrocytes during active myelinatio...
KEY FINDING: PTPRD is initially expressed in mature neurons in the embryonic CNS and later in oligodendroglial cells at postnatal stages.
Molecular Therapy: Methods & Clinical Development, 2021 • December 1, 2021
This study reports the unexpected finding that AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid (CSF). Different AAV serotypes, inclu...
KEY FINDING: AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid.
PLoS ONE, 2015 • September 18, 2015
This study investigates the role of SOCS3 in dendritic outgrowth and demyelination after spinal cord injury (SCI). It demonstrates that reducing SOCS3 expression enhances dendritic regeneration and pr...
KEY FINDING: IL-6 induces SOCS3 expression in NS-1 cells, leading to STAT3 activation, and SOCS3 negatively regulates STAT3 activation, inhibiting IL-6-induced neuritic outgrowth in vitro.
Cell Death and Disease, 2025 • January 29, 2025
The study demonstrates that the nuclear orphan receptor NR2F6 represses the expression of the activating receptor NKp46, an established key player in NK cell-mediated cytotoxicity during infection and...
KEY FINDING: NR2F6 represses the expression of the activating receptor NKp46, a key player in NK cell-mediated cytotoxicity.
Frontiers in Cellular Neuroscience, 2016 • February 9, 2016
This study challenges the dogma that the CNS is an alymphatic environment by investigating the expression of lymphatic markers LYVE-1 and PROX1 in the adult rat spinal cord. The research identified nu...
KEY FINDING: PROX1-immunoreactivity was detected in numerous nuclei evenly distributed throughout the gray and white matter of the rat adult spinal cord.
Dev Dyn, 2021 • June 1, 2021
Salamanders possess remarkable regenerative abilities, and the immune system plays a crucial role in these processes. Both innate and adaptive immune components are involved, with macrophages being pa...
KEY FINDING: Macrophages are recruited to the regenerating limb and heart, contributing to ECM remodeling, clearance of cellular debris and senescent cells.
Frontiers in Immunology, 2023 • January 12, 2023
HMGB1, a nuclear protein, is structurally divided into A-box, B-box, and acidic C-terminus. In a resting state, it regulates key nuclear activities. However, there are no related studies on the struct...
KEY FINDING: HMGB1 expression increases rapidly after SCI and lasts for an extended period, potentially influencing the severity and recovery process. It remains elevated even in chronic stages, warranting further investigation into its mechanisms and effects.
Neural Regeneration Research, 2021 • April 1, 2021
This study investigates synaptic remodeling in the mouse motor cortex following spinal cord hemi-section (SPH). The findings indicate that SPH leads to bilateral remodeling of postsynaptic dendritic s...
KEY FINDING: Spinal cord hemi-section (SPH) led to bilateral remodeling of dendritic spines in the motor cortex, with the main remodeling regions changing over time.