Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 751-760 of 1,773 results
Bioactive Materials, 2021 • March 2, 2021
This study evaluated the function of OXR1 in SCI and developed an available carrier for delivering the OXR1 plasmid (pOXR1). The particle size of pOXR1 was compressed to 58 nm, which suggests that pOX...
KEY FINDING: OXR1 expression increases after spinal cord injury and appears to have a protective effect.
Stem Cell Research & Therapy, 2021 • April 19, 2021
This study demonstrates that exosomes derived from miR-26a-modified mesenchymal stem cells (MSCs) can effectively promote axonal regeneration and functional recovery in a rat model of spinal cord inju...
KEY FINDING: Exosomes derived from miR-26a-modified MSCs (Exos-26a) promote axonal regeneration in a rat model of spinal cord injury.
Glia, 2014 • July 1, 2014
The study investigates the contribution of voltage-gated sodium channels to astrogliosis using an in vitro model of mechanical injury to astrocytes. Results demonstrate that wound closure after mechan...
KEY FINDING: Pharmacological treatment with TTX and KB-R7943, and knockdown of Nav1.5 mRNA attenuates wound closure after mechanical injury, involving both migration and proliferation.
Neurobiol Dis., 2016 • September 1, 2016
The study demonstrates that the thrombin receptor (PAR1) is a critical regulator of inflammation and astrogliosis after traumatic SCI. Targeting PAR1 genetically improved neurobehavioral outcomes, red...
KEY FINDING: PAR1 knockout mice displayed improved locomotor recovery after SCI and reduced signatures of inflammation and astrogliosis.
Cell Mol Neurobiol, 2017 • May 28, 2016
This study investigates the expression and role of Sam68, an RNA-binding protein, in spinal cord injury (SCI). The researchers found that Sam68 protein levels increase significantly after SCI in rats....
KEY FINDING: Sam68 protein levels are significantly increased in a rat model of spinal cord injury (SCI), peaking at day 3 and returning to normal by day 14.
International Journal of Molecular Sciences, 2014 • October 20, 2014
This study demonstrates that exercise preconditioning (EP) upregulates neuronal and astroglial heat shock protein 72 (HSP 72) in the spinal cord of rats, providing protection against spinal cord injur...
KEY FINDING: Exercised rats with spinal cord injury (SCI) had significantly higher levels of neuronal and astroglial HSP 72 compared to non-exercised rats with SCI.
PLoS ONE, 2017 • July 10, 2017
This study investigates regional differences in astrocyte expression of GFAP and ALDH1L1 across the brain and spinal cord during development and in response to demyelination. The results demonstrate t...
KEY FINDING: GFAP expression is higher in the developing and adult spinal cord compared to the brain.
PLoS ONE, 2014 • October 28, 2014
This study investigates the changes in protein abundance in the cerebrospinal fluid (CSF) of spinal cord injury (SCI) patients during the secondary phase of injury. The researchers identified eight pr...
KEY FINDING: Eight proteins showed differential abundance between complete and incomplete SCI at 1–8 days post-injury.
PLoS ONE, 2016 • July 22, 2016
This study investigated the serum levels of IGF-1 in patients after traumatic spinal cord injury over a three-month period, finding distinct patterns in the expression of IGF-1 regardless of the degre...
KEY FINDING: IGF-1 serum levels were significantly different from initial measurements at four, nine hours, seven, 14 days after injury as well as one, two and three months after injury.
PLoS ONE, 2016 • August 3, 2016
The study investigated the distinct effects of active muscle contraction, passive vibration, and whole-body heat stress on skeletal muscle gene regulation in humans. The purpose was to examine whether...
KEY FINDING: Repetitive active muscle contractions upregulated metabolic transcription factors and repressed MSTN.