Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination

This study investigates the role of PTPRD, a protein found in the central nervous system, in the myelination process. Myelination is crucial for nerve function. The research found that PTPRD is expressed in mature neurons and oligodendrocytes, cells responsible for myelination. Mutant mice lacking PTPRD showed a temporary delay in myelination during early development. The study also examined the role of PTPRD in remyelination after induced demyelination. The absence of PTPRD did not affect the remyelination process, suggesting it is not essential for this.

• 1
  PTPRD is initially expressed in mature neurons in the embryonic CNS and later in oligodendroglial cells at postnatal stages.
• 2
  In PTPRD mutants, oligodendrocyte differentiation was normal, but a transient myelination delay occurred at early postnatal stages.
• 3
  The remyelination process was not affected in the absence of PTPRD function after cuprizone-induced demyelination in adult animals.