Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 531-540 of 1,773 results
bioRxiv preprint, 2023 • August 4, 2023
This study investigates the role of Nox4 in reduced muscle specific force after spinal cord injury (SCI) using a conditional knockout mouse model. The results suggest a link between Nox4 expression in...
KEY FINDING: Peak twitch force in control mice after SCI was reduced by 42% compared to sham-operated controls.
Frontiers in Molecular Neuroscience, 2023 • August 24, 2023
This study investigates the changes in axonal mRNA profiles, particularly circular RNAs (circRNAs), after spinal cord injury (SCI) to understand their role in axonal regeneration. The researchers deve...
KEY FINDING: Axonal RNA is enriched using cold active proteases (CAP), which helps reduce artifacts during enzymatic digestion. Differentially expressed genes (DEGs), including circRNAs like Rims2, are detected after SCI.
European Journal of Medical Research, 2023 • August 3, 2023
This study investigates the effects of ferrostatin-1 on neurological function in mice after SCI, assessing neurophysiological performance 28 days post-SCI. The cEMP results demonstrated that the cEMP ...
KEY FINDING: Ferrostatin-1 promoted the rehabilitation of cortical evoked motor potential and BMS scores, synchronized with improvement in the histological manifestation of neuron survival and scar formation.
Regenerative Therapy, 2023 • March 31, 2023
This study demonstrates that Tanshinone IIA (TSIIA) protects motor neuron-like NSC-34 cells from lipopolysaccharide (LPS)-induced cell injury. The protective effect of TSIIA is mediated by the regulat...
KEY FINDING: TSIIA alleviates cell injury induced by LPS and increases TCTN2 expression in LPS-exposed NSC-34 cells.
Curr. Issues Mol. Biol., 2023 • September 13, 2023
The study aimed to identify transcriptome changes in the acute phase of SCI and the effect of Tamoxifen on those changes in a rat model of SCI. Results showed differential expression of genes related ...
KEY FINDING: SCI induces differential expression of 708 genes, with enriched pathways related to the SCI pathway and inflammatory response.
Neural Regeneration Research, 2024 • September 22, 2023
This study demonstrates that myelin debris induces lipid droplet accumulation in perilesional neurons after spinal cord injury (SCI), leading to lipotoxic damage and neuronal death. The study identifi...
KEY FINDING: Lipid droplets accumulate in perilesional spinal cord neurons after spinal cord injury in mice, induced by myelin debris.
NEURAL REGENERATION RESEARCH, 2024 • September 22, 2023
This study provides an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury, identifies sexual dimorphisms in terms of cytokine levels, and determines local cytokines t...
KEY FINDING: Pro-inflammatory cytokines like TNFα, IL-1β, and IL-6 are upregulated after SCI but return to normal levels within approximately 24 hours.
Scientific Reports, 2023 • November 14, 2023
This study investigated the effects of 4-methylumbelliferone (4-MU), an inhibitor of hyaluronan synthesis, on glial scar formation and functional recovery after spinal cord injury (SCI) in rats. Rats ...
KEY FINDING: A low dose of 4-MU (1.2 g/kg/day) reduced hyaluronan and chondroitin sulfate levels in uninjured spinal cords.
The Journal of Neuroscience, 2024 • January 3, 2024
This study investigates the role of astrocytic Rac1 in the development of hyperreflexia and spasticity following spinal cord injury (SCI) in mice. The researchers found that conditional knockout of Ra...
KEY FINDING: Astrocytic Rac1KO reduced SCI-related H-reflex hyperexcitability, indicating less spasticity.
Inflammation, 2024 • April 1, 2024
This study investigates the therapeutic potential of GlyNAC (glycine and N-acetylcysteine) in treating spinal cord injury (SCI) by reducing oxidative stress and skeletal muscle atrophy in a rat model....
KEY FINDING: GlyNAC treatment significantly elevated BBB scores from the first to the eighth week after intervention, suggesting improved motor function recovery in rats with SCI.