Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 421-430 of 1,773 results
The Journal of Neuroscience, 2024 • January 24, 2024
This study unveils that KCC2 controls spinal nociceptive synaptic strength via NMDA receptors in a cell type- and synapse type-specific manner. Spinal KCC2 impairment triggers pain hypersensitivity thr...
KEY FINDING: KCC2 inhibition preferentially augments presynaptic and postsynaptic NMDA receptor activity in spinal excitatory interneurons via α2δ-1.
CNS Neurosci Ther, 2024 • January 1, 2024
This study aimed to evaluate pathological changes in injured spinal cord and explore the possible mechanism related to spontaneous recovery after SCI. The findings indicate that miR-185-5p could be a ...
KEY FINDING: A time-dependent increase of GAP43 corresponded with the limited neurological recovery in rats with SCT.
Cell Research, 2024 • January 5, 2024
The study introduces TF-seqFISH, an image-based method to investigate spatial expression and regulation of TFs during human spinal cord development. By combining spatial transcriptomic data and single...
KEY FINDING: Identified the spatial distribution of neural progenitor cells characterized by combinatorial TFs along the dorsoventral axis.
Cells, 2024 • December 28, 2023
This study demonstrates that CREB1 plays a crucial role in generating induced GABAergic neuron cells (iGNs) originating from hMSCs. Transplanting iGNs to injured spinal cord provides a promising strat...
KEY FINDING: CREB1 overexpression in hMSCs induces differentiation into GABAergic neuron cells with upregulation of Map2 and GAD1.
Int. J. Mol. Sci., 2024 • December 26, 2023
This study investigates the potential of AKBA to ameliorate neuronal damage induced by acute spinal cord injury and elucidates the underlying mechanisms. The study found that AKBA, by engaging the Nrf...
KEY FINDING: AKBA reduces the expression of the pyroptotic initiator protein Caspase-1 by engaging the Nrf2-ROS-NLRP3 pathway, thus mitigating pyroptosis.
Basic Res Cardiol, 2024 • April 1, 2024
This study provides evidence suggesting that LPA contributes to myocardial I/R injury in mice by activating TRPV1-mediated signaling in the spinal cord. The study initially showed a strong association...
KEY FINDING: Myocardial I/R injury elevates CSF LPA levels, which is reduced by HA130 treatment.
Journal of Nanobiotechnology, 2024 • January 13, 2024
The study engineered HA-stabilized selenium nanoparticles (HA-Se NPs) specifically targeting the overexpressed CD44 receptor within the injured spinal cord, with the aim of mitigating secondary injury...
KEY FINDING: HA-Se NPs were easily prepared through direct reduction of seleninic acid in the presence of HA and exhibited a remarkable capacity to eliminate free radicals.
Molecular Pain, 2024 • January 23, 2024
This study aimed to investigate the anti-nociceptive effect of PD1 and investigate its molecular mechanism involving neuro-inflammatory processes. Our findings strongly suggest that PD1 exerts its analg...
KEY FINDING: PD1 significantly reversed the NCLDH-induced imbalance in neuro-inflammatory response and alleviated the symptoms of mechanical and thermal hyperalgesia.
Molecular Therapy, 2024 • April 1, 2024
This preclinical study demonstrates that targeting calpain1 in spinal motoneurons via intrathecal administration of AAV6-GFP-shRNA-CAPN1 reduces hindlimb muscle spasticity in adult rats with spinal co...
KEY FINDING: Intrathecal delivery of AAV6-shRNA-CAPN1 effectively reduced calpain1 expression in lumbar motoneurons of rats with SCI.
J South Med Univ, 2024 • January 1, 2024
This study explored the therapeutic potential of EMSCs-exo in mitigating secondary spinal cord injury by modulating neuroinflammation and oxidative stress. The research demonstrated that EMSCs-exo can...
KEY FINDING: EMSCs-exo treatment at 75 mg/L significantly increased Arg1 protein level and lowered iNOS protein expression in LPS-treated microglia (P<0.05).