Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 361-370 of 1,773 results
Int. J. Mol. Sci., 2023 • May 4, 2023
This study evaluated the feasibility of using autologous mesenchymal stem cell-derived extracellular vesicles (EVs) injected intrathecally to treat spinal cord injury (SCI) in pigs. The researchers op...
KEY FINDING: The study found that a specific method of preparing EVs, involving vortex mixing and filtration, resulted in more uniform and smaller vesicles.
Theranostics, 2023 • April 23, 2023
The study used a drug screening assay in larval zebrafish to identify Cimetidine, a histamine H2 receptor antagonist, as an immunomodulator after spinal cord injury. Cimetidine modulated the immune re...
KEY FINDING: Cimetidine, an over-the-counter H2 receptor antagonist, reduced il-1β expression in zebrafish and partially rescued impaired regeneration in the irf8 zebrafish mutant model for chronic inflammation.
Heliyon, 2023 • May 9, 2023
The study explores the efficacy of AgNPs on functional recovery after spinal cord injury (SCI) in a rat model. Local AgNPs delivery significantly improved locomotor function and provided neuroprotecti...
KEY FINDING: AgNPs delivery could significantly recover locomotor function and exert neuroprotection through reducing of pro-inflammatory M1 survival in SCI rat model.
Nanomaterials, 2023 • May 19, 2023
Gene therapy, particularly using adeno-associated viruses, has shown significant progress in treating neurological diseases, including spinal cord injury and Parkinson’s disease, by targeting the deli...
KEY FINDING: AuNpRs (gold nanoporous rods) function as ROS scavengers in DLR, lowering internal cellular conversion stress and enhancing the efficiency of DLR-induced dopaminergic (iDA) neurons from brain astrocytes.
Cell & Bioscience, 2023 • May 6, 2023
This study investigates the mechanisms underlying syrinx formation in syringomyelia, focusing on the role of ependymal cells and the TGFβR-Smad3 pathway. The researchers found that ependymal cells pro...
KEY FINDING: Syringomyelia induces syrinx formation and enlargement in the central canal, accompanied by the activation and proliferation of ependymal cells.
J Med Chem, 2023 • June 22, 2023
This study introduces novel biphenyl Au(III) complexes with bisphosphine ligands, demonstrating their stability and mild mitochondrial uncoupling activity. The complex Au-3 exhibits potent anticancer ...
KEY FINDING: The gold(III) complex Au-3 exhibits significant tumor growth inhibition in a metastatic TNBC mouse model.
NEURAL REGENERATION RESEARCH, 2023 • March 15, 2023
This study demonstrates that ferroptosis inhibition by Lip-1 maintains BSCB integrity after SCI and reduces vascular endothelial ferroptosis both in vitro and in vivo. Infiltrated immune cells, both m...
KEY FINDING: Liproxstatin-1 (Lip-1) reduces blood-spinal cord barrier (BSCB) disruption after spinal cord injury (SCI) by upregulating the expression of tight junction protein ZO-1 in endothelial cells.
Redox Biology, 2023 • May 30, 2023
This study investigates the neuroprotective effects of cyclic helix B peptide (CHBP) on spinal cord injury (SCI) in mice. The results indicate that CHBP improves functional recovery by alleviating pro...
KEY FINDING: CHBP significantly improves functional restoration after SCI.
Front. Neurol., 2023 • May 25, 2023
This case report presents a rare instance of a 3-year-old boy with a lumbosacral dumbbell-shaped epithelioid MPNST, highlighting its uncommon manifestation and genetic underpinnings. Genetic testing i...
KEY FINDING: The patient had a novel germline mutation in the SMARCB1 gene, inherited from his father, suggesting a “second-hit loss”.
Aging and Disease, 2024 • February 1, 2024
This study identifies Cathepsin B (CTSB) as a critical therapeutic target for ferroptosis in macrophages following spinal cord injury (SCI). The research demonstrates that inhibiting CTSB with CA-074-...
KEY FINDING: Excessive accumulation of iron and lipid peroxide occurs in the injured epicenter after SCI, indicating ferroptosis.