Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 261-270 of 1,773 results
Cellular and Molecular Neurobiology, 2023 • September 19, 2022
This study investigated the effects of trehalose-carnosine (Tre–car) conjugate on spinal cord injury (SCI) in both in vitro and in vivo models, focusing on inflammation, apoptosis, and zinc ion homeos...
KEY FINDING: Tre–car conjugate treatment counteracted the activation of the early inflammatory cascade, oxidative stress and apoptosis after SCI.
Frontiers in Neuroscience, 2022 • September 7, 2022
This study systematically reviews the therapeutic and prognostic role of HMGB1-targeted therapy in TSCI, identifying and analyzing 170 studies to narrow down to 12 based on inclusion/exclusion criteri...
KEY FINDING: HMGB1-targeted therapy improves locomotor function, reduces inflammation, attenuates edema, and reduces apoptosis in rats and mice with TSCI.
Stem Cell Research & Therapy, 2022 • January 1, 2022
This study investigates the therapeutic potential of miR-146a-5p-modified exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) in treating spinal cord injury (SCI) by targeting ...
KEY FINDING: Exosomes reduce the deleterious effects of neurotoxic astrocytes in vitro and in vivo.
BMC Neurology, 2022 • January 1, 2022
This study investigates the role of DNMT1 in neuropathic pain (NP) and explores the potential of RNA interference-mediated DNMT1 silencing to alleviate CCI-induced NP in rats. The study demonstrates t...
KEY FINDING: DNMT1 was upregulated in microglia of CCI rats, suggesting its involvement in neuropathic pain.
Nature Communications, 2022 • October 4, 2022
The study investigates the role of the alarmin IL-1α in spinal cord injury (SCI). IL-1α, primarily derived from damaged microglia, triggers a cascade of events leading to oligodendrocyte (OL) death, i...
KEY FINDING: Microglia-derived IL-1α induces OL death through the astrocytic and endothelial IL-1R1.
Materials Today Bio, 2022 • September 16, 2022
This study introduces a novel sEVs-NGL/T hydrogel for treating spinal cord injury (SCI). The hydrogel combines tannic acid's antioxidant properties with the therapeutic potential of mesenchymal stem c...
KEY FINDING: The sEVs-NGL/T hydrogel exhibited excellent antioxidant properties in vitro, effectively scavenging DPPH radicals and reducing H2O2 levels.
Journal of Neuroinflammation, 2022 • January 1, 2022
This review discusses the role of STING signaling in CNS injury, highlighting its involvement in inflammation, autophagy, necroptosis, ferroptosis, and pyroptosis. The cGAS–STING pathway is a key regu...
KEY FINDING: STING signalling is markedly increased in CNS injury, and STING agonists might facilitate the pathogenesis of CNS injury.
Neural Regeneration Research, 2023 • April 1, 2023
This study aimed to identify key circulating exosome-derived lncRNAs in a rat model of spinal cord injury and investigate their potential actions. The findings show that several circulating exosomal l...
KEY FINDING: There were distinctively different lncRNA and mRNA expression patterns between the spinal cord injury and control groups.
Neuron, 2022 • December 21, 2022
This study demonstrates that spared nerve injury (SNI) leads to mechanical hypersensitivity and neuropathic pain by triggering homeostatic reduction of inhibitory outputs from dorsal horn parvalbumin-...
KEY FINDING: Spared nerve injury (SNI) induces mechanical hypersensitivity and neuropathic pain through homeostatic reduction of inhibitory outputs from dorsal horn parvalbumin-positive (PV+) interneurons.
Frontiers in Immunology, 2022 • September 26, 2022
This study investigated the role of cannabinoid receptor-2 (CB2R) in neuroinflammation following spinal cord injury (SCI). The results showed that CB2R activation attenuated neuroinflammation by promo...
KEY FINDING: CB2R activation promotes M2 microglia differentiation, increases IL-10 expression, and inhibits M1 differentiation, decreasing IL-1b and IL-6 expression.