Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 181-190 of 1,773 results
Neural Regen Res, 2012 • June 1, 2012
This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, a...
KEY FINDING: Expression levels of numerous miRNAs change after SCI, indicating that miRNAs may play significant roles in responding to injury.
Neural Regen Res, 2012 • May 1, 2012
This study provides a comprehensive overview of Abra expression in the central nervous system of normal adult rats using confocal immunofluorescence. The findings reveal that Abra is widely distribute...
KEY FINDING: Abra is widely expressed in the rat central nervous system, including the cerebral cortex, hippocampus, basal ganglia, cerebellum, and spinal cord.
Neural Regen Res, 2012 • May 1, 2012
This study investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the cur...
KEY FINDING: TNF-α contributes to the induction of targeted migration of MSCs towards damaged sites in the spinal cord, and activates the extracellular signal-regulated kinase and p38 pathways in MSCs.
Regeneration, 2014 • June 11, 2014
The study investigates the transcriptional response of regenerating DRG neurons and associated cells to signaling from the blastema in axolotls. A DRG−blastema co-culture model was used to test the hy...
KEY FINDING: Over 1500 genes change expression in DRG and the nerve trunk during the first 5 days of culture, indicating nerve recovery and regeneration after dissection.
Mediators of Inflammation, 2015 • March 9, 2015
This review discusses the inflammatory responses after nervous system trauma, comparing CNS and PNS inflammation regarding magnitude, cell types, and effector molecules. In SCI, secondary damage invol...
KEY FINDING: Neutrophils, initially linked to deleterious effects in CNS trauma due to the release of proinflammatory cytokines, may also have proregenerative functions.
Molecular Therapy — Methods & Clinical Development, 2014 • January 15, 2014
The study demonstrates that lumbar puncture of a nonhuman AAV leads to wide and stable distribution of the vector along the spinal cord in adult mice. AAVrh10 efficiently and specifically infects neur...
KEY FINDING: AAVrh10 efficiently transduces both sensory neurons in the dorsal root ganglia (DRG) and motor neurons in the spinal cord after intrathecal administration.
Int J Dev Biol, 2015 • January 1, 2015
This study investigates the role of transmembrane voltage potentials (Vmem) in regulating apoptosis and proliferation during embryonic CNS development using Xenopus laevis embryos. Disrupting local Vm...
KEY FINDING: Disrupting local bioelectric signals in the developing neural tube increases apoptosis and decreases proliferation, leading to brain mispatterning.
Regeneration, 2014 • September 3, 2014
This study compares the early transcriptional response of iris to lentectomy between young and old axolotl larvae that differed in regeneration competence. The many highly differentially expressed gen...
KEY FINDING: Over 3700 genes were identified as differentially expressed between young (7 days post-hatching) and old (3 months post-hatching) axolotl larvae.
Biomedicines, 2014 • October 31, 2014
HGF was molecularly cloned as a growth factor for hepatocytes. The scatter factor, originally identified as a fibroblast-derived cell motility factor for epithelial cells, was shown to be an identical...
KEY FINDING: The intravenous/systemic administration of recombinant HGF protein has been well tolerated in phase I/II clinical trials.
Journal of Sleep Research, 2024 • January 11, 2024
This case study investigates the use of a rocking bed with vestibular stimulation to improve sleep in a 12-year-old boy with a severe mitochondrial disease and sleep disorder. The study found signific...
KEY FINDING: Sleep duration increased by 25% during the final 4-week intervention period compared to baseline.