Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,731-1,740 of 1,773 results
BMC Biology, 2009 • January 13, 2009
Microarray analysis and 454 cDNA sequencing were used to identify nerve-dependent and independent gene expression changes during limb regeneration in the Mexican axolotl. The results show that limb re...
KEY FINDING: Considerable similarity was observed between NR and DL transcriptional programs at 5 and 14 days post amputation (dpa).
BMC Genomics, 2009 • January 13, 2009
This study provides the first DNA sequence data from a large salamander genome, revealing that genic regions, particularly introns, are significantly expanded compared to other vertebrates. The analys...
KEY FINDING: Axolotl introns are significantly longer (10x) than orthologous vertebrate introns, contributing substantially to the large genome size.
Biomaterials, 2009 • April 1, 2009
This study investigates surface immobilization to deliver complexed DNA (lipoplexes) from a multiple channel bridge in order to promote transgene expression in the injured spinal cord using low quanti...
KEY FINDING: Fibronectin, an ECM protein, produced greater gene expression levels and immobilization efficiencies compared with collagen and laminin.
The Journal of Neuroscience, 2009 • March 25, 2009
This study demonstrates that activated macrophages can simultaneously promote axon regeneration and neurotoxicity in the CNS. Zymosan-activated macrophages (ZAMs) initially enhance axon growth towards...
KEY FINDING: Activated macrophages (ZAMs) increase axon growth towards macrophage foci in the spinal cord, indicating a pro-regenerative effect.
The Journal of Neuroscience, 2009 • January 28, 2009
This study demonstrates that the EGF receptor, when activated in astrocytes, triggers a signaling pathway involving Akt, Tuberin, Rheb, and mTOR. The research also shows that this pathway is functiona...
KEY FINDING: EGF activates the mTOR pathway in cultured adult spinal cord astrocytes through Akt-mediated phosphorylation of Tuberin, leading to Rheb activation.
Molecular Therapy, 2009 • June 1, 2009
This study investigates a combination of microsurgery and gene therapy to repair spinal dorsal root injuries, common in brachial plexus injuries. Microsurgery restores anatomical continuity, while gen...
KEY FINDING: Microsurgery combined with gene therapy promotes efficient axonal regrowth of DR ganglion central axons into the spinal cord.
Regen Med, 2009 • March 1, 2009
The study demonstrates that a Cx43 carboxyl-terminal peptide (ACT1) can accelerate wound closure and improve the quality of skin healing in both mouse and pig models. ACT1 treatment leads to reduced i...
KEY FINDING: Cx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin.
The Journal of Neuroscience, 2009 • April 29, 2009
This study demonstrates that α9 integrin expression promotes neurite outgrowth on tenascin-C (TN-C) both in vitro and in vivo, suggesting a potential therapeutic strategy for enhancing axon regenerati...
KEY FINDING: Expression of α9 integrin in PC12 cells and adult rat DRG neurons promotes extensive neurite outgrowth on tenascin-C in vitro.
Nat Neurosci, 2009 • July 1, 2009
This report demonstrates that chromatin remodeling enzymes HDAC1/2 regulate oligodendrocyte specification and differentiation, at least in part, by inhibiting β-catenin/TCF7L2 complex formation. The s...
KEY FINDING: HDAC1 and HDAC2 are essential for oligodendrocyte formation, and their deletion leads to a complete loss of oligodendrocytes.
J Neurochem, 2009 • July 1, 2009
The study demonstrates that inhibiting NF-κB in astrocytes promotes axonal sparing and sprouting after spinal cord contusion injury, contributing to improved functional recovery. Retrograde tracing sh...
KEY FINDING: Inhibition of NF-κB in astrocytes leads to reduced inflammation and improved functional recovery after spinal cord injury.