Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,741-1,750 of 1,773 results
PLoS ONE, 2009 • July 14, 2009
This study demonstrates that lentiviral-mediated RNAi can efficiently silence GFAP and vimentin expression in cultured astrocytes. The use of Lv-shGFAP and Lv-shVIM vectors resulted in a significant d...
KEY FINDING: Lv-shGFAP and Lv-shVIM vectors effectively silenced GFAP and vimentin expression in cultured astrocytes.
Molecular Therapy, 2009 • July 21, 2009
The study demonstrates that lentiviral delivery of DNROCK to neurons can effectively target the RhoA-ROCK signal pathway, promoting regenerative sprouting of injured axons after CNS injury. DNROCK enh...
KEY FINDING: DNROCK expression in DRG neurons promotes neurite growth on myelin proteins in vitro, overcoming the inhibitory effects of CNS myelin.
Genesis, 2009 • November 1, 2009
This study generated an allelic series of OMgp in mice to investigate its role in axon regeneration. The series includes a null allele with a LacZ reporter, a clean null allele, and a conditional alle...
KEY FINDING: The study successfully generated an OMgp allelic series in mice, including a null allele with a LacZ reporter, one without a reporter gene (clean null), and a conditional allele.
Glia, 2010 • February 1, 2010
This study investigates the molecular mechanisms underlying the upregulation of CHL1 expression in reactive astrocytes following spinal cord injury (SCI). It demonstrates that bacterial lipopolysaccha...
KEY FINDING: LPS upregulates CHL1 expression in astrocytes via a PI3K/PKCδ-dependent pathway.
Exp Neurol, 2010 • May 1, 2010
This study demonstrates that overexpression of NGF distal to a nerve bifurcation enhances the accuracy of sensory axon reinnervation following nerve transection in a rat femoral nerve model. The enhan...
KEY FINDING: NGF overexpression significantly increased the accuracy of saphenous branch axon reinnervation to the appropriate nerve branch.
Science, 2009 • October 23, 2009
Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane p...
KEY FINDING: PTPσ binds with high affinity to neural CSPGs. Binding involves the chondroitin sulfate chains and a specific site on the first immunoglobulin-like domain of PTPσ.
Nat Neurosci, 2009 • November 1, 2009
This study identifies GPR17 as a negative regulator of oligodendrocyte differentiation and myelination. Sustained expression of GPR17 inhibits oligodendrocyte maturation, while GPR17 deletion accelera...
KEY FINDING: GPR17 is restricted to oligodendrocyte lineage cells but downregulated during the peak period of myelination and in adulthood.
J. Cell. Mol. Med., 2011 • February 1, 2011
The study investigates the de-differentiation potential of murine glomerular epithelial cells in vitro, focusing on the role of EMT in imparting plasticity to GPECs. Results demonstrate that GPECs of ...
KEY FINDING: GPECs from adult murine kidneys can undergo EMT in vitro, leading to the generation of cells expressing CD24, CD44, and CD29 surface antigens.
Curr Opin Organ Transplant, 2010 • February 1, 2010
iPS cells hold great promise due to their potential to circumvent ethical and immunological challenges associated with ES cells. However, their use is limited by reprogramming efficiency and therapeut...
KEY FINDING: Somatic cells can be reprogrammed to a pluripotent state using retroviral transduction of only 4 genes: Sox2, Oct4/Pou5f1, c-Myc, and Klf4. These are termed the “Yamanaka factors”.
Nat Neurosci, 2009 • November 1, 2009
The study demonstrates that Mst3b mediates the effects of trophic factors in stimulating axon outgrowth in adult RGCs and DRG neurons. Mst3b exerts its effects through changes in its kinase activity. ...
KEY FINDING: Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal root ganglion (DRG) neurons.