Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,721-1,730 of 1,773 results
The Journal of Neuroscience, 2008 • September 17, 2008
This study demonstrates the critical role of CD11b+ myeloid cells in axon regeneration after neural injury, using a transgenic mouse model for selective cell ablation. The absence of CD11b+ cells lead...
KEY FINDING: Selective ablation of CD11b+ cells impairs axonal regeneration and locomotor function recovery after sciatic nerve injury.
J Neurosci Res, 2009 • February 1, 2009
This study demonstrates that human fetal cortical NSCs can be induced to express spinal motor neuron characteristics in vitro by bFGF. bFGF enhances the expression of ventral markers such as Olig2 in ...
KEY FINDING: bFGF induces human NSCs to express the motor neuron marker Hb9.
Cell Mol Neurobiol, 2009 • October 17, 2008
The study successfully cloned the full-length PDGF-C gene from Gekko japonicus and analyzed its sequence, revealing similarities to PDGF-C in other species. Expression analysis showed that PDGF-C is w...
KEY FINDING: The PDGF-C gene of Gekko japonicus was cloned and found to have a transcript size of 2.8 kb.
Exp Neurol, 2009 • January 1, 2009
This study investigated the potential of IGF-I gene delivery to promote corticospinal axon regeneration and neuronal survival after spinal cord injury in adult rats. IGF-I secreting cell grafts were u...
KEY FINDING: IGF-I secreting cell grafts promoted growth of raphespinal and coerulospinal axons into the lesion/graft site after C3 dorsal column transections in adult rats.
Cytotechnology, 2006 • December 5, 2006
This study introduces an optimized method for preparing highly pure astrocyte cultures from rat spinal cord. The method involves modifications to the isolation procedures and cultivation conditions, i...
KEY FINDING: The optimized method consistently produced astrocyte cultures with greater than 99% purity, as confirmed by immunofluorescence staining against GFAP and OX-42.
Molecular Therapy, 2009 • February 1, 2009
The study engineered plasmid-loaded multiple channel bridges for spinal cord regeneration. These bridges support cellular processes and promote gene transfer at the injury site. Subcutaneous implantat...
KEY FINDING: Plasmid-loaded bridges support substantial cell infiltration and aligned cells within the channels.
Neural Development, 2008 • December 8, 2008
This study investigates the role of Semaphorin-6A (Sema6A) and its receptors, Plexin-A2 (PlxnA2) and Plexin-A4 (PlxnA4), in the guidance of corticospinal tract (CST) axons. The results show that Sema6...
KEY FINDING: Sema6A mutants exhibit hypoplasia and misrouting of the corticospinal tract, affecting the number of axons reaching the hindbrain and spinal cord.
The Journal of Neuroscience, 2008 • December 10, 2008
This study investigates the role of MMP-9 in glial scar formation and astrocyte migration following spinal cord injury. The findings suggest that MMP-9 facilitates glial scar formation and astrocyte m...
KEY FINDING: Wild-type mice developed a more severe glial scar compared to MMP-9 null mice after spinal cord injury, indicating MMP-9's role in glial scar formation.
Exp Neurol, 2009 • March 1, 2009
This study developed an in vitro model to examine the ability of olfactory bulb-derived OEG to promote axon regeneration of DRG neurons on a myelin substrate. The results showed that OEG promote a hig...
KEY FINDING: OEG enhance DRG axon outgrowth on myelin: More neurons generate axons, and their average length is almost twice that of those grown on myelin alone.
BioMed Central, 2009 • January 6, 2009
This study demonstrates that the sea cucumber Holothuria glaberrima can fully regenerate its radial nerve cord (RNC) after transection, restoring its morphology and cellular composition within a month...
KEY FINDING: Holothuria glaberrima can regenerate its radial nerve cord within a month following transection.