Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,611-1,620 of 1,773 results
International Journal of Molecular Sciences, 2020 • July 30, 2020
This study investigates the effects of Nogo-A antibodies on neuronal survival and neurite outgrowth, focusing on the direct interaction of these antibodies with Nogo-A expressed in neurons. The result...
KEY FINDING: Nogo-A antibodies (both monoclonal and polyclonal) enhance neurite outgrowth in cultured cerebellar granule neurons.
Stem Cells International, 2012 • August 28, 2012
The review highlights the limitations of current SCI treatments and the need for innovative approaches to facilitate neural regeneration and functional improvement. Combination therapies, incorporatin...
KEY FINDING: Combination therapies, involving neurotrophins and cell grafts, cotransplantation of different grafts, or anti-inhibitory therapies, show enhanced efficacy compared to individual treatments.
Neural Regen Res, 2021 • January 1, 2021
This review provides a comprehensive assessment of Schwann cell (SC) function post-peripheral nerve injury (PNI), focusing on SC interactions with macrophages and fibroblasts, which significantly infl...
KEY FINDING: Schwann cells (SCs) recruit macrophages to the injury site through the expression of monocyte chemoattractant protein-1 and leukemia inhibitory factor, aiding in debris clearance following Wallerian degeneration.
Neural Regen Res, 2021 • January 1, 2021
This study investigates the role of Krüppel-like factor-4 (Klf4) in axonal regeneration after nervous system damage in mammals. The researchers found that Klf4 knockout promotes peripheral nerve regen...
KEY FINDING: Klf4 expression in dorsal root ganglion sensory neurons was significantly reduced after peripheral axotomy, suggesting a link between sciatic nerve regeneration and Klf4.
International Journal of Molecular Sciences, 2020 • August 24, 2020
The study investigates the postnatal development of rat primary motor cortex layer V (M1LV) neurons, focusing on the axon initial segment (AIS) maturation and its impact on neuronal function. Key find...
KEY FINDING: Cell growth in the first two postnatal weeks leads to a substantial decline in neuronal input resistance, requiring larger input current for action potential firing.
Frontiers in Neurology, 2020 • August 4, 2020
This study constructed a ceRNA network based on the differential expression profiles of whole substantia nigra tissues of normal and PD patients, and the network was subsequently identified which reve...
KEY FINDING: Identified 31 DE lncRNAs and 1,828 DEmRNAs and constructed a ceRNA network associated with PD, including 9 lncRNAs, 18 miRNAs, and 185 mRNAs.
Cells, 2020 • August 29, 2020
Peripheral nerve injuries (PNI) affect approximately 1 million people worldwide annually, and long-gap nerve injuries present significant clinical challenges, often requiring autologous nerve transpla...
KEY FINDING: Schwann cell transplantation can help overcome hurdles and reverse the inhibitory microenvironment into a permissive niche for regeneration.
Journal of Neuroinflammation, 2020 • August 25, 2020
Following SCI, neuronal pyroptosis lasted longer and occurred farther away from the injury core compared with that of neuronal apoptosis. Microglial Hv1 deficiency downregulated microglial ROS generat...
KEY FINDING: Neuronal apoptosis peaked earlier than pyroptosis after SCI, but pyroptosis lasted longer.
Military Medical Research, 2020 • September 7, 2020
This study demonstrates the feasibility of chemically converting human and mouse astrocytes into motor neuron-like cells using a defined cocktail of small molecules. The induced motor neuron-like cell...
KEY FINDING: Human astrocytes can be rapidly and efficiently converted into motor neuron-like cells by treatment with defined small molecules, achieving over 85% conversion.
Frontiers in Immunology, 2020 • August 14, 2020
This mini-review discusses the role of fibrotic scar formation in neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer’s disease (AD). The r...
KEY FINDING: Fibrotic scarring in neurodegenerative diseases like ALS, MS, and AD involves complex interactions between various cell types, including astrocytes, microglia, fibroblasts, and immune cells.