Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,541-1,550 of 1,773 results
Cerebral Cortex, 2020 • March 1, 2020
The study examines the functional maturation and integration of neuronal precursors in the adult murine piriform cortex, focusing on whether these precursors become equivalent to neighboring principal...
KEY FINDING: Young complex cells receive less synaptic input and fire action potentials at lower frequencies compared to mature principal neurons, similar to neonatal principal neurons.
Cells, 2019 • October 30, 2019
The study investigated the effect of autophagy induction by genetic and pharmacological manipulation on motor nerve regeneration using models of nerve axotomy and compression. ATG5 or NAD+-dependent de...
KEY FINDING: Overexpression of ATG5 in spinal motor neurons stimulates mTOR-independent autophagy and improves motor axonal regeneration.
International Journal of Molecular Sciences, 2019 • November 3, 2019
The review focuses on the role of the blood-brain barrier (BBB) and its tight junctions (TJs) in age-related brain disorders. It discusses how age, age-related pathologies, and immune system aging aff...
KEY FINDING: Aging negatively impacts BBB function, increasing paracellular permeability in the aged human brain.
Exp Eye Res, 2020 • January 1, 2020
This study investigates the spatiotemporal distribution of chondroitin sulfate proteoglycans (CSPGs) following optic nerve injury in rodents, finding similarities to CSPG changes after spinal cord inj...
KEY FINDING: Optic nerve crush (ONC) in mice and rats leads to increased expression of aggrecan, brevican, phosphacan, neurocan, and versican in the optic nerve and retina, mirroring changes seen after spinal cord injury.
Neural Regen Res, 2020 • November 8, 2019
This study examined the expression of Slit1–3 and Robo1–2 in the adult mouse peripheral nervous system after sciatic nerve transection injury using qRT-PCR, western blot, and immunostaining. The study...
KEY FINDING: In the dorsal root ganglion (DRG), Slit1-3 and Robo1-2 mRNA expression were initially downregulated within 4 days after injury, but Slit1-3 mRNA expression remained upregulated during regeneration from 4-14 days after injury.
Frontiers in Immunology, 2019 • November 1, 2019
This study identifies foamy macrophages in the reactive Axolotl spinal cord meninges, revealing their participation in spinal cord regeneration. These cells accumulate in fibrotic meninges during amph...
KEY FINDING: Foam cells (foamy macrophages) accumulate in the invasive fibrotic meninges during gap regeneration of transected adult Axolotl spinal cord and may act beneficially.
Cellular and Molecular Neurobiology, 2020 • November 28, 2019
This study investigates the role of the Notch-Hes signaling pathway in regulating oligodendrocyte maturation in the developing central nervous system. The study identifies Notch1 and Notch3 as recepto...
KEY FINDING: Notch1 and Notch3 are expressed in oligodendrocyte precursor cells (OPCs) during gliogenesis, and Hes5 is the major Notch downstream transcription factor that is transiently expressed in OPCs.
Annals of Translational Medicine, 2019 • October 1, 2019
This study investigates the role of HSC70 in C2C12 myoblast differentiation, finding that HSC70 is up-regulated during differentiation. The research demonstrates that HSC70 knockdown inhibits myoblast...
KEY FINDING: HSC70 expression is significantly up-regulated during C2C12 myoblast differentiation.
Biochem Biophys Res Commun, 2020 • February 19, 2020
This study investigates the role of JunB in Xenopus tail regeneration, revealing its importance in regulating cell proliferation. The research demonstrates that JunB expression is activated and sustai...
KEY FINDING: The expression of junb is rapidly activated and sustained during tail regeneration.
Neural Regen Res, 2020 • December 10, 2019
This study introduces a method for directly tracing and quantifying sensory axon regeneration in vivo using electroporation and fluorescent labeling. The research provides a detailed time course of se...
KEY FINDING: Sensory axons regenerate slowly during the first day after injury but show steady growth from the second day onwards.