Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,441-1,450 of 1,773 results
Cell Transplantation, 2018 • June 1, 2018
Spinal cord injury (SCI) is a heavy burden on patient physiology and psychology. According to our previous work and the advancements in SCI research, ‘microenvironment imbalance’ is the main cause of ...
KEY FINDING: Microenvironment imbalance is defined as an increase in inhibitory factors and decrease in promoting factors for tissues, cells and molecules at different times and spaces.
International Journal of Molecular Sciences, 2018 • June 5, 2018
This study compares the effects of IGF-1 and BMP-7 on osteogenic differentiation of human mesenchymal stem cells (MSCs) from reaming debris (RMSC) and iliac crest bone marrow (BMSC) in vitro. The resu...
KEY FINDING: BMSC showed a more sensitive reaction towards stimulation with IGF-1, leading to a significantly higher degree of osteogenic differentiation compared to stimulation with BMP-7.
Front. Cell. Neurosci., 2018 • May 23, 2018
This study investigates the role of Apolipoprotein E (ApoE) in spinal cord injury (SCI) using Apoe knockout (KO) mice. The study demonstrates that Apoe deficiency exacerbates inflammation, oxidative s...
KEY FINDING: Apoe−/− mice showed retarded functional recovery and a larger lesion size compared to wild-type mice after SCI, indicating that Apoe deficiency worsens the outcomes after SCI.
Biotechnology Reports, 2018 • January 1, 2018
This study explores the use of the Proseek Single-Plex Protein Assay Kit System for detecting sAxl and Gas6 in HGG patients' blood, aiming for more sensitive detection than standard ELISA methods. The...
KEY FINDING: The Proseek method demonstrates higher sensitivity in detecting lower concentrations of Gas6 compared to the DuoSet sandwich ELISA method.
Brain, 2018 • June 14, 2018
This study introduces a novel immune-evasive gene switch (dox-i-ChABC) that enables regulated delivery of ChABC in the injured mammalian spinal cord, providing an experimental tool to control delivery...
KEY FINDING: A novel immune-evasive gene switch (dox-i-ChABC) enables regulated delivery of ChABC in the injured mammalian spinal cord.
Neural Regeneration Research, 2018 • June 1, 2018
This study investigates the role of RXRα in tail and spinal cord regeneration in adult newts, focusing on its interaction with RARβ. The research demonstrates that RXRα protein levels are downregulate...
KEY FINDING: RXRα protein levels decrease during tail and spinal cord regeneration in adult newts, while RXRα mRNA levels increase.
Neural Regeneration Research, 2018 • June 1, 2018
This study examined the effect of local BMP7 injection on neuronal regeneration and motor function recovery in rats with acute spinal cord injury (SCI). The results showed that BMP7 promoted motor fun...
KEY FINDING: Local injection of BMP7 increased BBB scores in rats with SCI at 1, 2, 4, and 8 weeks post-operation, indicating improved motor function.
Iranian Journal of Basic Medical Sciences, 2018 • June 1, 2018
The present study was designed to comprehensively review evidence from animal studies discussing the fate of neurons after TSCI in rats. In the current study, we found that different populations of ne...
KEY FINDING: Both necrotic and apoptotic neuronal deaths occur after TSCI, though necrosis is the prominent mechanism.
Neurotherapeutics, 2018 • June 8, 2018
Axonal regeneration relies on the expression of regenerative associated genes within a coordinated transcriptional programme, which is finely tuned as a result of the activation of several regenerativ...
KEY FINDING: HDAC inhibitors (HDACi) can promote neurite extension and growth cone remodeling by increasing acetylation of H3 at K9/14, requiring transcription.
Mol Cell Neurosci, 2018 • October 1, 2018
This study investigates the role of astrocytic transglutaminase 2 (TG2) in CNS injury outcomes. It demonstrates that reducing TG2 in astrocytes enhances their neuroprotective capabilities in vitro, pa...
KEY FINDING: Knocking down TG2 in astrocytes increases their ability to protect neurons from oxygen glucose deprivation/reperfusion injury.