Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,431-1,440 of 1,773 results
Cerebral Cortex, 2018 • July 1, 2018
This study investigates the fate of immature neurons in the adult murine piriform cortex using transgenic mice. It challenges the notion that these cells disappear with age. The research demonstrates...
KEY FINDING: Immature neurons in the piriform cortex do not vanish with age; instead, they progressively mature into glutamatergic neurons.
Therapeutics and Clinical Risk Management, 2018 • January 1, 2018
This prospective safety study evaluated the impact of BMP-7 on cytokine expression in non-union therapy by comparing IGF-1, PDGF-AB, and TGF-β levels in patients treated with ABG alone versus ABG with...
KEY FINDING: IGF-1 levels were generally higher in the ABG-only group (G2) compared to the BMP-7 group (G1), but the overall course of expression was similar.
Neural Regeneration Research, 2018 • April 1, 2018
This study investigates the effect of ROCK inhibitors, Y27632 and fasudil, on microglial migration in the spinal cord and the underlying mechanisms. The researchers found that these inhibitors promote...
KEY FINDING: Y27632 and fasudil increased microglial migration, suggesting ROCK inhibition promotes microglial motility.
SMALL GTPASES, 2020 • January 1, 2020
Adult CNS axons fail to regenerate after injury due to extrinsic inhibitory factors and a low intrinsic capacity for axon growth, unlike developing neurons. ARF6 and Rab11, small GTPases, regulate pol...
KEY FINDING: ARF6 activation prevents the axonal transport of integrins in Rab11 endosomes in mature CNS axons, restricting them to the somato-dendritic domain.
eNeuro, 2018 • May 7, 2018
This study examined the role of Sema3A signaling in motor axon reinnervation of the adult NMJ using a nerve crush model and inducible knockout mice. The researchers found that Sema3A and Npn1 mRNA lev...
KEY FINDING: Sema3A and Npn1 mRNA levels decrease in response to denervation, contrary to previous findings that reported an upregulation of Sema3A after nerve crush injury.
Dev Neurobiol, 2018 • October 1, 2018
This integrated analysis substantiates the hypothesis that dynamic chromatin accessibility contributes to the developmental decline in axon growth ability and influences the efficacy of pro-regenerati...
KEY FINDING: Overall closure of chromatin in sub-networks of genes associated with axon growth was detected in the developing cortex.
The Journal of Neuroscience, 2018 • June 27, 2018
The study investigates the functional role of autophagy in oligodendrocytes (OLs) after spinal cord injury (SCI) using pharmacological and genetic approaches in mice. Results show that although autoph...
KEY FINDING: SCI leads to upregulation of Atg5, an essential autophagy gene, but the autophagic flux is impaired, indicated by elevated levels of p62/SQSTM1.
Neural Plasticity, 2018 • April 18, 2018
The review discusses how the extracellular environment of the CNS, particularly the ECM and myelin, influences plasticity, sprouting, and axonal regeneration after spinal cord injury. It highlights th...
KEY FINDING: CSPGs and tenascins, which form perineuronal nets (PNNs), enhance synaptic stability in the adult CNS but contribute to the inhibitory glial scar after injury, preventing axonal regeneration.
Neural Plasticity, 2018 • April 3, 2018
This study investigates the response of astrocytes in the spinal ventral horn to peripheral nerve injury (PNI) and their potential role in nerve regeneration. The researchers found that astrocytes bec...
KEY FINDING: Astrocytes in the spinal ventral horn are activated in the early stages following sciatic nerve injury, but this activation diminishes in the chronic stage.
Molecular Therapy: Nucleic Acids, 2018 • June 1, 2018
This study demonstrates the potential of combining LNA-modified AON gapmers with a fibrin hydrogel for in situ gene silencing at a spinal cord injury (SCI) lesion site. The fibrin hydrogel acts as a d...
KEY FINDING: LNA gapmers were effectively developed against RhoA and GSK3b, two gene targets aiming at enhancing axonal regeneration.