Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,411-1,420 of 1,773 results
The Journal of Neuroscience, 2018 • February 14, 2018
This study investigates the role of Sox2 in oligodendrocyte development and myelination in the brain and spinal cord. The researchers used genetic approaches in mice to disrupt Sox2 function in oligod...
KEY FINDING: Sox2 is expressed in OPCs in the postnatal and adult CNS, and transiently upregulated in newly differentiated OLs during developmental myelination and in newly regenerated OLs during remyelination.
Scientific Reports, 2018 • January 17, 2018
Results from this study reveal several key findings. First, these data reinforce lessons from the recent publication of the lamprey genome, which is that the lamprey CNS expresses homologs of a large ...
KEY FINDING: SCI in lamprey induces expression of many transcripts associated with regeneration in the mammalian PNS, illustrating the power of this organism as a model for identifying and studying highly conserved, fundamental, pro-regenerative molecular pathways.
Frontiers in Cellular Neuroscience, 2018 • February 27, 2018
This study compares the expression of Musashi (Msi) proteins in the spinal cord ependymal cells of Xenopus laevis and Ambystoma mexicanum at different life stages and during regeneration. The researc...
KEY FINDING: Msi-1 expression is high in regeneration-competent Xenopus tadpoles and is upregulated after injury in adult Axolotls, indicating its importance for spinal cord regeneration.
Neurosci. Bull., 2018 • January 22, 2018
This study investigates the role of miR-146b in sciatic nerve regeneration, demonstrating that miR-146b directly targets KLF7. Inhibition of miR-146b promotes Schwann cell proliferation, migration, an...
KEY FINDING: miR-146b directly targets KLF7 by binding to its 3'UTR, suppressing its expression.
Front. Cell. Neurosci., 2018 • January 9, 2018
This study demonstrates that Neuregulin 1 (NRG1) exerts neuroprotective effects on motoneurons (MNs) under chronic excitotoxicity and enhances neurite growth, suggesting the NRG1-ErbB system as a pote...
KEY FINDING: Addition of recombinant human NRG1 (rhNRG1) to spinal cord organotypic cultures (SCOCs) significantly increased motoneuron (MN) survival under chronic excitotoxicity.
Frontiers in Molecular Neuroscience, 2018 • January 12, 2018
This study profiled the responses to spinal cord injury both at transcriptome and translatome level, and find them to be highly uncoupled, highlighting the importance of post-transcriptional gene regula...
KEY FINDING: A substantial post-transcriptional regulation of gene expression occurs following spinal cord injury.
Neural Regen Res, 2018 • January 1, 2018
This review summarizes experimental evidence that reveals novel roles for Wnt signaling in the injured CNS, and discusses possible mechanisms by which Wnt ligands could overcome molecular barriers inh...
KEY FINDING: Activation of Wnt/β-catenin signaling in retinal neurons and radial glia promotes neuronal survival and axonal growth.
Neural Regen Res, 2018 • January 1, 2018
This study investigates the neuroprotective effects of rutin in a rat model of spinal cord injury (SCI). The researchers hypothesized that rutin's mechanism of action involves inhibiting the p38 mitog...
KEY FINDING: Rutin increased Basso, Beattie and Bresnahan locomotor function scores, indicating improved motor function in rats with spinal cord injury.
Cellular and Molecular Life Sciences, 2018 • February 21, 2018
This study investigates the role of Aurora kinase B (AurkB) in the development and regeneration of spinal motor neurons in zebrafish. The researchers found that AurkB is expressed in the spinal cord a...
KEY FINDING: AurkB is expressed in the spinal cord and motor neurons of developing zebrafish, suggesting a role in neuronal development.
Int. J. Biol. Sci., 2018 • January 15, 2018
This study investigates the role of miR-21-5p in fibrotic scar formation after spinal cord injury (SCI). The findings demonstrate that TGF-β1 enhances miR-21-5p expression in spinal fibroblasts, promo...
KEY FINDING: TGF-β1 enhances miR-21-5p expression in primary spinal fibroblasts, and regulates the expression of fibrosis-related genes.