Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,401-1,410 of 1,773 results
Cell Tissue Res., 2018 • January 1, 2018
This review discusses recent advancements in in vivo cell fate reprogramming, focusing on neuronal reprogramming in the mammalian brain and spinal cord. It critically reviews the cellular sources, rep...
KEY FINDING: Astrocytes, the most abundant glial cells in the CNS, can be reprogrammed into neurons in vivo using cell type-restricted promoters in viral vectors and genetic lineage-tracing mouse lines.
Data in Brief, 2018 • November 4, 2017
The study investigates spinal cord regeneration in larval zebrafish after mechanical transection, focusing on the restoration of anatomical continuity. Spreading of fluorescently-labelled dextran alon...
KEY FINDING: Anatomical continuity is rapidly restored after complete spinal cord transection in larval zebrafish.
Front. Neural Circuits, 2017 • November 23, 2017
This review highlights the contributions of Xenopus laevis as a model organism for studying spinal cord formation, development, function, and regeneration. The advantages of using Xenopus include its ...
KEY FINDING: Xenopus laevis has been instrumental in identifying factors involved in neural induction, such as Noggin, Chordin, and Follistatin, all inhibitors of the Bone Morphogenetic Protein (BMP) pathway and Fibroblast Growth Factor (FGF).
Frontiers in Cellular Neuroscience, 2017 • November 29, 2017
This study investigates the role of VEGF in functional recovery after complete spinal cord transection (ST) in neonatal and adult rats. The research found that VEGF levels are higher in neonates after...
KEY FINDING: VEGF levels are significantly higher in neonatal rats (P1) compared to adult rats (P28) after complete spinal cord transection.
Experimental & Molecular Medicine, 2017 • December 15, 2017
This study investigated the effect of silencing Patched-1 (PTC1) and PTC2 genes on Hedgehog (Hh) pathway-mediated recovery from spinal cord injury (SCI) in a rat model. The results showed that silenci...
KEY FINDING: Silencing PTC1 and PTC2 genes via lentivirus-mediated RNAi led to elevated expression levels of Shh, Gli-1, Smo, and Nestin in the spinal cords of rats with SCI.
Neurobiology of Disease, 2018 • March 1, 2018
This study demonstrates that one of the signaling cascades induced by RARβ activation in injured neurons is endogenous RA signaling in NG2+ cells and neurons at the injury site. The RA paracrine signa...
KEY FINDING: Neuronal RARβ activation induces endogenous RA signaling in NG2+ cells and neurons at the injury site after spinal cord injury.
PLoS ONE, 2018 • January 2, 2018
This study investigated the distribution and cellular targeting of intravenously infused MSCexos in rats with SCI. The MSCexos were detected in the contused regions of the spinal cord and the spleen. ...
KEY FINDING: IV delivered MSCexos traffic to contusive SCI sites but not uninjured spinal cord tissue.
npj Regenerative Medicine, 2016 • June 9, 2016
This study demonstrates a rapid and efficient method for gene knockout in axolotls using electroporation of CAS9 protein–gRNA complexes. The method allows for tissue-specific and temporally controlled...
KEY FINDING: Electroporation of CAS9 protein–gRNA complexes is more efficient than plasmid-based CRISPR systems for gene knockout.
International Journal of Molecular Sciences, 2018 • January 9, 2018
This study investigated the effects of intraarticular administration of MSCs in a rat model of shoulder arthritis induced by MIA. The findings indicate that MSCs can inhibit central sensitization of p...
KEY FINDING: Intraarticular injection of MSCs decreased the expression of CGRP in the spinal dorsal horn, indicating a suppression of central sensitization of pain.
Neural Regeneration Research, 2017 • December 1, 2017
Reactive astrogliosis occurs after central nervous system (CNS) injuries whereby resident astrocytes form rapid responses along a graded continuum. Recent use of various genetic tools has made tremend...
KEY FINDING: Reactive astrocytes isolated from injured spinal cord form scarring astrocytes when transplanted into injured spinal cord, but revert in retrograde to naive astrocytes when transplanted into naive spinal cord.