Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish

Cellular and Molecular Life Sciences, 2018 · DOI: https://doi.org/10.1007/s00018-018-2780-5 · Published: February 21, 2018

Neurology Genetics

Simple Explanation

Aurora kinase B (AurkB) is usually known for its role in cell division. This study found that AurkB is also important in nerve cells, specifically in the growth and repair of nerve fibers (axons) in zebrafish. The researchers found that AurkB is present in the nerve cells of the developing zebrafish brain and spinal cord. By using drugs and genetic methods to reduce AurkB activity, they observed stunted and abnormal nerve fibers. Conversely, increasing AurkB levels led to more extensive nerve fiber growth. Also, blocking AurkB activity slowed down the recovery of nerve fibers after injury. These findings suggest that AurkB plays a crucial role in nerve development and axon growth.

Study Duration

Not specified

Participants

Zebrafish embryos and larvae

Evidence Level

Level III, experimental study

Key Findings

1
AurkB is expressed in the spinal cord and motor neurons of developing zebrafish, suggesting a role in neuronal development.
2
Inhibition of AurkB activity impairs axonal outgrowth in developing zebrafish spinal motor neurons.
3
Pharmacological inhibition of AurkB activity delays regenerative growth of laser-mediated severed motor axons.

Research Summary

This study investigates the role of Aurora kinase B (AurkB) in the development and regeneration of spinal motor neurons in zebrafish. The researchers found that AurkB is expressed in the spinal cord and motor neurons of developing zebrafish and that manipulation of AurkB activity affects axonal outgrowth. Inhibition of AurkB also impairs the regeneration of severed motor axons, suggesting a role for AurkB in nerve repair.

Practical Implications

Therapeutic Target

AurkB might be a potential therapeutic target for promoting axonal outgrowth and regeneration after traumatic brain and/or spinal cord injuries.

Drug Development

Developing drugs that can modulate AurkB activity may help improve nerve regeneration and functional recovery after injury.

Understanding Neuronal Development

AurkB's role in neurons extends beyond cell division, highlighting the multi-functional nature of cell cycle proteins.

Study Limitations

1
The exact mechanisms by which AurkB regulates axonal growth and regeneration are not fully understood.
2
The study primarily used zebrafish models, and further research is needed to confirm these findings in mammalian systems.
3
The specificity of AZD1152 inhibition is not cell-specific.

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