Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,421-1,430 of 1,773 results
Environmental Epigenetics, 2016 • September 16, 2016
The review summarizes the evidence linking BPA exposure to obesity and the involvement of epigenetic mechanisms. Early-life exposure to BPA is particularly effective in predisposing individuals to wei...
KEY FINDING: Early-life exposure to BPA can predispose individuals to weight gain and metabolic disturbances such as obesity and diabetes.
Frontiers in Pharmacology, 2018 • February 15, 2018
The study evaluated the therapeutic efficacy of in vivo and ex vivo triple gene therapy (VEGF, GDNF, and NCAM) in a rat model of stroke. Results showed that both in vivo and ex vivo gene therapy reduc...
KEY FINDING: Triple gene therapy (VEGF, GDNF, and NCAM) reduced the volume of brain cortex infarct compared to control groups.
J Cell Mol Med, 2018 • May 1, 2018
This study investigates the therapeutic potential of FGF1 in treating spinal cord injury (SCI) by delivering FGF1 using an adeno-associated virus (AAV) vector. The results demonstrate that AAV-mediate...
KEY FINDING: Overexpression of FGF1 via AAV delivery reduces tissue loss and protects neurons after spinal cord injury.
Front. Cell. Neurosci., 2018 • March 6, 2018
The review addresses limitations in current in vitro models of spinal motor neuron (MN) degeneration, particularly regarding the use of immature neurons and the absence of complex cell-cell interactio...
KEY FINDING: Current in vitro models of spinal motor neuron degeneration often rely on immature neurons, which do not fully represent the characteristics of mature neurons affected in diseases like ALS.
Neuron, 2018 • April 18, 2018
The study demonstrates that astrocytes express the inward-rectifying K+ channel Kir4.1 around motor neurons in a VGLUT1-dependent manner. Loss of astrocyte-encoded Kir4.1 selectively altered fast a-mo...
KEY FINDING: Kir4.1 is upregulated in astrocytes around high-activity alpha motor neurons (MNs).
Scientific Reports, 2018 • March 15, 2018
This study investigates the use of lentiviral vectors encoding NgR1-shRNA to decrease NgR1 expression and promote nerve regeneration and functional recovery after SCI in rats. The results indicated th...
KEY FINDING: Rats treated with LV-NgR1 shRNA showed significantly elevated BBB scores from 6 to 8 weeks after SCI, indicating improved motor function compared to the control group.
Neural Regen Res, 2018 • March 1, 2018
This study investigated the role of the protocadherin alpha (Pcdhα) cluster in axon growth and myelination in the developing central nervous system. The researchers found that deletion of the Pcdhα cl...
KEY FINDING: Axon length was significantly decreased in Pcdhα mutant neurons compared to wild-type neurons in culture.
Neural Regen Res, 2018 • March 1, 2018
This study investigated the effects of immediate and delayed xenon post-conditioning on spinal cord ischemia/reperfusion injury (SCI/RI) in rabbits, focusing on microglial activation and inflammatory ...
KEY FINDING: Delayed xenon post-conditioning significantly improved neurological function in rabbits and attenuated the microglia-mediated inflammatory response.
Cell Reports, 2018 • April 10, 2018
The study used a genome-wide loss-of-function screen to identify factors limiting axonal regeneration from cerebral cortical neurons in vitro, identifying 580 significant phenotypes. Key pathways iden...
KEY FINDING: A genome-wide loss-of-function screen identified 580 genes that limit axonal regeneration from cerebral cortical neurons in vitro.
Cell Stem Cell, 2018 • July 5, 2018
The article reviews the conflicting evidence surrounding adult hippocampal neurogenesis in humans, triggered by two recent publications reaching opposite conclusions. It discusses the methodologies us...
KEY FINDING: Adult neurogenesis can be detected in the human hippocampus in the same location and numbers as expected based on work in rats, as indicated by the presence of BrdU-positive neurons.