CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability

This study investigates whether stimulating the regenerative gene expression program can improve neurological recovery in chronic spinal cord injury (SCI) with severe disability. The researchers delivered a CBP/p300 activator (CSP-TTK21) to mice with SCI and observed enhanced regenerative signaling and axon growth. The findings suggest that pharmacological CBP/p300 activation can promote axonal growth in chronic SCI, even with severe neurological disability.

• 1
  CSP-TTK21 enhanced classical regenerative signalling in dorsal root ganglia sensory neurons but not cortical motor neurons.
• 2
  The CBP/p300 activator TTK21 significantly reduced axonal retraction and promoted axonal growth of motor corticospinal and of sensory DRG neurons.
• 3
  TTK21 led to an increased number of vGlut1, but not of vGat, boutons opposed to motor neurons in the ventral horn of L1-3 spinal sections below the injury site.